Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Scientists spot sneaky “neurodegenerative” iron at the European synchrotron

26.09.2007
Scientists suspect that iron accumulation plays a role in neurodegenerative processes such as Parkinson’s disease, but its distribution in neurons has never been observed because of the lack of techniques to do so. Until today.

Researchers from CNRS at the University of Bordeaux (France), University of Sevilla (Spain), INSERM Grenoble Institute of Neurosciences (France) and ESRF have studied the iron distribution in an in vitro model of neuronal cells that produce dopamine. Dopamine is a neurotransmitter, a chemical messenger between nerve cells in the mammalian brain.

Because dopamine can form stable complexes with iron, Richard Ortega, from the cellular chemical imaging group in Bordeaux, believed that dopamine may exert a protective effect by buffering iron in dopaminergic neurons and that this system might be at fault in Parkinson’s disease.

To test this hypothesis, the team used the new nanoprobe imaging experimental station recently developed at the European Synchrotron Radiation Facility to study the distribution of elements in cells. The resolution of 90 nm allowed scientists to visualize the elements distribution in the neurotransmitter vesicles. The nanoprobe consists on exciting the sample with a strongly focused X-ray beam and collecting the characteristic fluorescence signal that is re-emitted. This allows showing the different trace elements in a point, and then the sample is scanned point by point to form a complete multi-element image of the cells.

... more about:
»Distribution »Iron »dopamine »vesicles

The team shows that iron is stored within dopamine vesicles inside the neuronal cells. This is the first evidence of iron-dopamine co-localization in neuro-vesicles. The results also explain that when dopamine production is obstructed, the iron in the vesicles drastically decreases. This new function of dopamine vesicles in iron storage is of critical importance to understand the molecular mechanisms involved in Parkinson’s disease. In this neurological disorder, dopamine vesicular storage has been found impaired. According to these results, this would increase the levels of highly toxic iron-dopamine complexes in the neurons. The results are published in PLoS ONE on September 26.

The synchrotron nano-imaging station offers a new tool for researchers involved not only in the study of neurodegenerative diseases but also in many other fields where the determination of metal ions distribution at the subcellular level is important such as: metal toxicology, chemical carcinogenesis, and cellular pharmacology of inorganic compounds. This is one of the reasons why the team decided to submit their results in an open access journal such as PLoS ONE: “ We want the different scientific communities to know that this machine is available, and the best way is by letting everyone have access to the results”, explains Peter Cloetens, in charge of the station at ESRF.

Andrew Hyde | alfa
Further information:
http://www.plosone.org
http://www.plosone.org/doi/pone.0000925

Further reports about: Distribution Iron dopamine vesicles

More articles from Life Sciences:

nachricht Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery
20.01.2017 | GSI Helmholtzzentrum für Schwerionenforschung GmbH

nachricht Seeking structure with metagenome sequences
20.01.2017 | DOE/Joint Genome Institute

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>