Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Bacteria Genome Research Could Save Orchards and Assist Blood Transfusions

21.08.2007
Research led by the University Warwick into the genomes of two bacteria could save orchards from a previously almost incurable disease and also assist in treating complications arising from human blood transfusions.

The researchers were interested in how the bacteria naturally produced a family of chemicals called desferrioxamines. Desferrioxamine E is produced by the bacterium Erwinia amylovora. The bacterium uses it to damage apple or pear trees and acquire iron from them. This allows it to establish an infection that leads to the economically-damaging agricultural disease known as “Fire Blight” that can sweep through an orchard if the infected trees are not removed. The bacterium Streptomyces coelicolor produces desferrioxamine B, which is used to treat iron overload in humans – for instance following extensive blood transfusions.

By studying the genomes of the two bacteria, the researchers were able to work out that each uses a similar biochemical pathway to produce desferrioxamines. In both cases they use a “remarkable” trimerisation-macrocyclisation reaction cascade in the key step. The researchers purified the enzyme responsible and showed that it could catalyse the reaction cascade in a test tube.

The current industrial process to create desferrioxamine B relies on the fermentation of the bacterium Streptomyces pilosus. The Warwick-led research has identified how Streptomyces bacteria create it using only four enzyme catalysts and four different building blocks. In contrast, the laboratory synthesis of desferrioxamine B requires 10 steps and uses numerous chemicals. Harnessing the enzymes may result in much cheaper pharmaceuticals based on desferrioxamine B and manipulating them could lead to the creation of new orally-active analogues of this important pharmaceutical.

... more about:
»bacterium »desferrioxamine »orchard

The new understanding of how desferrioxamine E is created by Erwinia amylovora opens the way for the creation of new chemical inhibitors that may prevent this bacterium from inflicting Fire Blight on orchards

The research was led by Professor Greg Challis from the University of Warwick and involved colleagues from the University of Warwick and the Universidad Nacional Autonoma de Mexico. It was published online in Nature Chemical Biology on Sunday 19th of August.

Richard Fern | alfa
Further information:
http://www.warwick.ac.uk

Further reports about: bacterium desferrioxamine orchard

More articles from Life Sciences:

nachricht Researchers identify potentially druggable mutant p53 proteins that promote cancer growth
09.12.2016 | Cold Spring Harbor Laboratory

nachricht Plant-based substance boosts eyelash growth
09.12.2016 | Fraunhofer-Institut für Angewandte Polymerforschung IAP

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>