Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Milestone in the regeneration of brain cells: Supportive cells generate new nerve cells

21.08.2007
The research group of Prof. Dr. Magdalena Götz at the Institute of Stem Cell Research of the GSF – National Research Centre for Environment and Health, and the Ludwig Maximilians University, Munich, has achieved an additional step for the potential replacement of damaged brain cells after injury or disease: functional nerve cells can be generated from astroglia, a type of supportive cells in the brain by means of special regulator proteins.

The majority of cells in the human brain are not nerve cells but star-shaped glia cells, the so called “astroglia”. “Glia means “glue”, explains Götz. “As befits their name, until now these cells have been regarded merely as a kind of “putty” keeping the nerve cells together.

A couple of years ago, the research group had been already able to prove that these glia cells function as stem cells during development. This means that they are able to differentiate into functional nerve cells. However, this ability gets lost in later phases of development, so that even after an injury to the adult brain glial cells are unable to generate any more nerve cells.

In order to be able to reverse this development, the team studied what molecular switches are essential for the creation of nerve cells from glial cells during development. These regulator proteins are introduced into glial cells from the postnatal brain, which indeed respond by switching on the expression of neuronal proteins.

... more about:
»Brain »generate »glia »glia cells »means »nerve cells

In his current work, Dr. Benedikt Berninger, was now able to show that single regulator proteins are quite sufficient to generate new functional nerve cells from glia cells. The transition from glia-to-neuron could be followed live at a time-lapse microscope. It was shown that glia cells need some days for the reprogramming until they take the normal shape of a nerve cell. “These new nerve cells then have also the typical electrical properties of normal nerve cells”, emphasises Berninger. “We could show this by means of electrical recordings”.

“Our results are very encouraging, because the generation of correctly functional nerve cells from postnatal glia cells is an important step on the way to be able to replace functional nerve cells also after injuries in the brain,” underlines Magdalena Götz.

Michael van den Heuvel | alfa
Further information:
http://www.gsf.de/neu/Aktuelles/Presse/2007/isf_en.php

Further reports about: Brain generate glia glia cells means nerve cells

More articles from Life Sciences:

nachricht Researchers at IST Austria define function of an enigmatic synaptic protein
22.11.2017 | Institute of Science and Technology Austria

nachricht Women and lung cancer – the role of sex hormones
22.11.2017 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Nanoparticles help with malaria diagnosis – new rapid test in development

The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.

Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

Researchers at IST Austria define function of an enigmatic synaptic protein

22.11.2017 | Life Sciences

Fine felted nanotubes: CAU research team develops new composite material made of carbon nanotubes

22.11.2017 | Materials Sciences

Women and lung cancer – the role of sex hormones

22.11.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>