Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

One step closer to transplanting stem cells in the brain

20.08.2007
Stem cells transplanted into the brains of mice generate more numerous and more mature nerve cells if the brain cells called astrocytes are not activated. This discovery at the Sahlgrenska Academy is an important step forward for stem cell research.

The study was performed by a research team at the Center for Brain Repair and Rehabilitation at the Sahlgrenska Academy. The findings are being presented in the prestigious scientific journal Stem Cells.

Many see the transplantation of stem cells and activation of the body's own stem cells as a promising future treatment for several neurological disorders.

"Intensive research is under way around the world to find ways to get stem cells to develop into the right kind of cells, to migrate through brain tissue to the right place and then survive. Even though much work remains to be done before patients benefit from this knowledge, our findings are an important step in that direction," says Milos Pekny, professor at the Sahlgrenska Academy, Göteborg University in Sweden.

Astrocytes are a type of cells in the central nervous system that control many neurological functions, including the capacity of the brain to repair itself. The research team has previously shown that reduced activation of astrocytes leads to prolonged healing of the damage, but that ultimately the regeneration of the nerve fibers and synapses of nerve cells is enhanced. Decreased activation of astrocytes also yields better results when cells are transplanted into the retina.

"Astrocytes are also activated when stem cells are transplanted into the brain, and we show that this negatively affects the development of the stem cells," says Milos Pekny.

The scientists used genetically modified mice whose astrocytes are unable to produce two proteins called GFAP and vimentin. Such astrocytes have a limited capacity to become activated. When neural stem cells are cultured with these modified astrocytes, the generation of nerve cells was increased by 65 percent. At the same time, the formation of new astrocytes rose by 124 percent.

In the study, stem cells were transplanted into the mouse hippocampus, an area where new nerve cells are generated also in adults. When mice with limited astrocyte activation were used as recipients, there was an increase in the number of nerve cells and astrocytes generated from the transplanted stem cells. The newly generated nerve cells were also more mature than those in normal mice.

"These studies were carried out in collaboration with Professor Peter Eriksson, a great friend, a fantastic colleague, and a pioneer in human neural stem cell research, whom we lost very suddenly just a few days ago," says Milos Pekny.

Tina Zethraeus | alfa
Further information:
http://stemcells.alphamedpress.org/

Further reports about: activation astrocyte endocarditis nerve cells stem cells transplanted

More articles from Life Sciences:

nachricht Nesting aids make agricultural fields attractive for bees
20.07.2017 | Julius-Maximilians-Universität Würzburg

nachricht The Kitchen Sponge – Breeding Ground for Germs
20.07.2017 | Hochschule Furtwangen

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Manipulating Electron Spins Without Loss of Information

Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.

For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...

Im Focus: The proton precisely weighted

What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.

To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...

Im Focus: On the way to a biological alternative

A bacterial enzyme enables reactions that open up alternatives to key industrial chemical processes

The research team of Prof. Dr. Oliver Einsle at the University of Freiburg's Institute of Biochemistry has long been exploring the functioning of nitrogenase....

Im Focus: The 1 trillion tonne iceberg

Larsen C Ice Shelf rift finally breaks through

A one trillion tonne iceberg - one of the biggest ever recorded -- has calved away from the Larsen C Ice Shelf in Antarctica, after a rift in the ice,...

Im Focus: Laser-cooled ions contribute to better understanding of friction

Physics supports biology: Researchers from PTB have developed a model system to investigate friction phenomena with atomic precision

Friction: what you want from car brakes, otherwise rather a nuisance. In any case, it is useful to know as precisely as possible how friction phenomena arise –...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

»We are bringing Additive Manufacturing to SMEs«

19.07.2017 | Event News

The technology with a feel for feelings

12.07.2017 | Event News

Leipzig HTP-Forum discusses "hydrothermal processes" as a key technology for a biobased economy

12.07.2017 | Event News

 
Latest News

Researchers create new technique for manipulating polarization of terahertz radiation

20.07.2017 | Information Technology

High-tech sensing illuminates concrete stress testing

20.07.2017 | Materials Sciences

First direct observation and measurement of ultra-fast moving vortices in superconductors

20.07.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>