Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

One step closer to transplanting stem cells in the brain

20.08.2007
Stem cells transplanted into the brains of mice generate more numerous and more mature nerve cells if the brain cells called astrocytes are not activated. This discovery at the Sahlgrenska Academy is an important step forward for stem cell research.

The study was performed by a research team at the Center for Brain Repair and Rehabilitation at the Sahlgrenska Academy. The findings are being presented in the prestigious scientific journal Stem Cells.

Many see the transplantation of stem cells and activation of the body's own stem cells as a promising future treatment for several neurological disorders.

"Intensive research is under way around the world to find ways to get stem cells to develop into the right kind of cells, to migrate through brain tissue to the right place and then survive. Even though much work remains to be done before patients benefit from this knowledge, our findings are an important step in that direction," says Milos Pekny, professor at the Sahlgrenska Academy, Göteborg University in Sweden.

Astrocytes are a type of cells in the central nervous system that control many neurological functions, including the capacity of the brain to repair itself. The research team has previously shown that reduced activation of astrocytes leads to prolonged healing of the damage, but that ultimately the regeneration of the nerve fibers and synapses of nerve cells is enhanced. Decreased activation of astrocytes also yields better results when cells are transplanted into the retina.

"Astrocytes are also activated when stem cells are transplanted into the brain, and we show that this negatively affects the development of the stem cells," says Milos Pekny.

The scientists used genetically modified mice whose astrocytes are unable to produce two proteins called GFAP and vimentin. Such astrocytes have a limited capacity to become activated. When neural stem cells are cultured with these modified astrocytes, the generation of nerve cells was increased by 65 percent. At the same time, the formation of new astrocytes rose by 124 percent.

In the study, stem cells were transplanted into the mouse hippocampus, an area where new nerve cells are generated also in adults. When mice with limited astrocyte activation were used as recipients, there was an increase in the number of nerve cells and astrocytes generated from the transplanted stem cells. The newly generated nerve cells were also more mature than those in normal mice.

"These studies were carried out in collaboration with Professor Peter Eriksson, a great friend, a fantastic colleague, and a pioneer in human neural stem cell research, whom we lost very suddenly just a few days ago," says Milos Pekny.

Tina Zethraeus | alfa
Further information:
http://stemcells.alphamedpress.org/

Further reports about: activation astrocyte endocarditis nerve cells stem cells transplanted

More articles from Life Sciences:

nachricht Transport of molecular motors into cilia
28.03.2017 | Aarhus University

nachricht Asian dust providing key nutrients for California's giant sequoias
28.03.2017 | University of California - Riverside

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Challenging European Research Project to Develop New Tiny Microscopes

The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.

To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Transport of molecular motors into cilia

28.03.2017 | Life Sciences

A novel hybrid UAV that may change the way people operate drones

28.03.2017 | Information Technology

NASA spacecraft investigate clues in radiation belts

28.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>