Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Mouse Study Suggests Anxiety Disorders Take Root in Infancy

28.03.2002


The absence of a key signaling protein in the brain during infancy could lead to anxiety disorders later in life, scientists say. According to findings published today in the journal Nature, mice lacking the receptor protein for the chemical messenger serotonin just after birth exhibit abnormal anxiety as adults.



Researchers have known for some time that mice genetically engineered to lack the receptor for serotonin, a neurotransmitter, show anxiety-like behavior. But the new results go one step further, revealing when in life and where in the brain the link between serotonin receptors and anxiety behavior is forged. As in earlier studies, the investigators, led by René Hen of Columbia University, first created a line of so-called knockout mice that lacked the gene encoding the receptor protein. Those mice showed the expected signs of anxiety, such as moving around less open spaces and taking longer to start eating in new environments as compared with normal animals. To determine which of the two receptor populations--the one in the forebrain or the one in the brainstem--is most critical in that regard, the team then crossed the knockout mice with a line engineered to activate receptor expression in particular brain regions. The resulting line of double-transgenic "rescue" animals expressed the serotonin receptors only in the forebrain, but exhibited normal anxiety behavior. Further tests, in which the drug doxycycline was used to suppress the receptors in mice at various stages of development, showed that eliminating the receptors in juvenile or adult mice did not elicit over-anxiousness.

"Forebrain serotonin receptors are needed during the development of newborns to modulate the predisposition to anxiety-like behavior, but are no longer critical during adult life," Solomon Snyder of Johns Hopkins University explains in a commentary accompanying the report. He proposes that variations in serotonin-sensitive neurons and serotonin receptors early in life might account for the importance of maternal nurturing in preventing emotional disorders later in life. Rats that were not groomed sufficiently as pups by their mothers display elevated levels of anxiety as adults, he notes. "Assuming that we can equate developmental stages in mice and humans," Snyder reflects, "these findings might be relevant to brain development and the genesis of anxiety in people too."

Kate Wong | Scientific American

More articles from Life Sciences:

nachricht Transport of molecular motors into cilia
28.03.2017 | Aarhus University

nachricht Asian dust providing key nutrients for California's giant sequoias
28.03.2017 | University of California - Riverside

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Challenging European Research Project to Develop New Tiny Microscopes

The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.

To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Transport of molecular motors into cilia

28.03.2017 | Life Sciences

A novel hybrid UAV that may change the way people operate drones

28.03.2017 | Information Technology

NASA spacecraft investigate clues in radiation belts

28.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>