Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Zebrafish: It's not your parents' lab rat

31.07.2007
Zebrafish research provides answers about neurological development

Zebrafish cost about a dollar at the pet store. They grow from eggs to hunting their own food in three days. Adults can lay up to 500 eggs at once… and you have more in common with them than you think.

"For all their differences, humans and zebrafish aren't that dissimilar," said Rice University zebrafish expert Mary Ellen Lane. "For every zebrafish gene we isolate, there is a related gene in humans."

In her most recent work, Lane, graduate students Catherine McCollum and Shivas Amin, and undergraduate Philip Pauerstein zeroed in on a gene called LMO4 that's known to play roles in both cell reproduction and in breast cancer. Using the tools of biotechnology, the team studied zebrafish that couldn't transcribe the LMO4 gene, and they observed marked enlargement in both the forebrain and optical portions of the embryos. When they overexpressed the LMO4 gene, making more protein than normal, those same areas shrank. The study will appear later this year in the journal Developmental Biology.

... more about:
»Embryo »LMO4 »zebrafish

"The study suggests that LMO4 independently regulates two other genes that promote growth in those areas of the embryo," said Lane, assistant professor of biochemistry and cell biology. "It fills in another piece of the bigger picture of what's going on during neurological development."

Zebrafish -- like rats and fruit flies before them -- are becoming regular contributors on research ranging from cancer to cocaine addiction. For example, zebrafish were used a landmark 2005 study that led scientists to the human gene that regulates skin color.

Lane's zebrafish studies explore one the major unexplained areas in developmental biology -- how the brain and central nervous system develop. It helps that zebrafish embryos grow from just a single cell to having a forebrain, hindbrain, spinal column and eye within a scant 24 hours. It also helps that the embryos are transparent and develop outside their mothers' bodies -- and can thus been seen under a microscope at every step of their development.

"It's a beautiful organism for experiment," Lane said. "It develops in a very regular way, so any abnormality is easy to spot, even for undergraduates with only a few days training."

Jade Boyd | EurekAlert!
Further information:
http://www.rice.edu

Further reports about: Embryo LMO4 zebrafish

More articles from Life Sciences:

nachricht Research team creates new possibilities for medicine and materials sciences
22.01.2018 | Humboldt-Universität zu Berlin

nachricht Saarland University bioinformaticians compute gene sequences inherited from each parent
22.01.2018 | Universität des Saarlandes

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Artificial agent designs quantum experiments

On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.

We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Thanks for the memory: NIST takes a deep look at memristors

22.01.2018 | Materials Sciences

Radioactivity from oil and gas wastewater persists in Pennsylvania stream sediments

22.01.2018 | Earth Sciences

Saarland University bioinformaticians compute gene sequences inherited from each parent

22.01.2018 | Life Sciences

VideoLinks Wissenschaft & Forschung
Overview of more VideoLinks >>>