Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Sequencing method yields fuller picture

18.07.2007
Sequence data for both chromosomes can be inferred under the right circumstances, USC biologists say.

University of Southern California biologists have developed a method for sequencing both chromosomes of an organism.

Their study appears in a recent issue of Genome Research.

The statistical method is significant because when researchers announce they have sequenced an organism’s genome, they really mean that they have created a mosaic of two chromosomes, said USC computational biologist Lei Li.

... more about:
»DNA »biologist »chromosomes »junk DNA

“A mosaic means it’s not real,” Li said.

Lead author and former graduate student Jong Hyun Kim, advised by Li and USC University Professor Michael Waterman, was able to infer a complete sequence of the chromosomes of Ciona intestinalis, a marine invertebrate, from existing sequencing data.

Kim’s method exploited the high rate of genetic mutations in the organism. Other organisms with high genetic variability, such as certain fish, also may be suitable.

Because the human genome has a relatively low mutation rate, the method cannot be applied to people.

However, Kim said, the method might be useful in sequencing parts of the human genome that display high variability.

As a by-product of their analysis, the researchers added to growing evidence that so-called junk DNA may have a function after all.

Recent studies have shown that junk DNA expresses proteins which may regulate gene function, and that sections of junk DNA have been highly conserved during evolution, suggesting that they play an important role.

The Genome Research study confirms that many short sections of junk DNA are highly conserved, Li and Kim said.

Carl Marziali | EurekAlert!
Further information:
http://www.usc.edu

Further reports about: DNA biologist chromosomes junk DNA

More articles from Life Sciences:

nachricht Water forms 'spine of hydration' around DNA, group finds
26.05.2017 | Cornell University

nachricht How herpesviruses win the footrace against the immune system
26.05.2017 | Helmholtz-Zentrum für Infektionsforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

How herpesviruses win the footrace against the immune system

26.05.2017 | Life Sciences

Water forms 'spine of hydration' around DNA, group finds

26.05.2017 | Life Sciences

First Juno science results supported by University of Leicester's Jupiter 'forecast'

26.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>