Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Variant Creutzfeldt-Jakob Disease – prion amplification breakthrough brings new insights and hopes for a blood test

05.07.2007
Researchers have shown that a recently developed laboratory method to amplify prions (Protein Misfolding Cyclic Amplification) can be applied to variant CJD.

The work was carried out by scientists at the National CJD Surveillance Unit at the University of Edinburgh, the Scottish National Blood Transfusion Service, Neuropathogenesis Unit and CSL Behring. It is published this month in the Journal of Pathology.

The team, led by Dr. Mark Head, also shows for the first time that variant CJD prions can be amplified from brain tissue samples using normal blood cells to improve the sensitivity of current detection tests. This method has the potential to be applied on other tissues and fluids, including blood. The prion amplification is dependent on genetic factors, similar to those influencing susceptibility to variant CJD.

Background

... more about:
»Brain »CJD »Prion »amplification

Creutzfeldt-Jakob disease (CJD) seems to result from conversion of a normal protein in the body to an abnormal form that is self-replicating as a prion and toxic to the brain. In variant CJD, this occurs after infection by the bovine spongiform encephalopathy (BSE) prion. Following exposure to BSE, there is a long silent period before the prion spreads to the brain and causes neurological symptoms. It is now clear that during this silent period individuals can pass variant CJD prions on to others by blood transfusion and there are also fears that the disease might also be spread by certain kinds of surgery.

One way to protect blood recipients from this threat is to screen blood donations for prions, but efforts to develop such a test have proven difficult, partly because of the very low level of prions that are likely to be present in blood.

The team stress that the work is at an early stage, but co-researcher Professor James Ironside, of the National CJD Surveillance Unit at the University of Edinburgh, said “These new findings provide us with an invaluable tool to study one of the fundamental aspects of variant CJD and take us one step closer towards supporting a test to screen for individuals who might inadvertently pass this disease on to others through blood transfusion, organ donation or surgery.”

Jennifer Beal | alfa
Further information:
http://www.wiley.co.uk
http://www.interscience.wiley.com/thejournalofpathology

Further reports about: Brain CJD Prion amplification

More articles from Life Sciences:

nachricht Could this protein protect people against coronary artery disease?
17.11.2017 | University of North Carolina Health Care

nachricht Microbial resident enables beetles to feed on a leafy diet
17.11.2017 | Max-Planck-Institut für chemische Ökologie

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

Im Focus: Wrinkles give heat a jolt in pillared graphene

Rice University researchers test 3-D carbon nanostructures' thermal transport abilities

Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

NASA detects solar flare pulses at Sun and Earth

17.11.2017 | Physics and Astronomy

NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures

17.11.2017 | Health and Medicine

The importance of biodiversity in forests could increase due to climate change

17.11.2017 | Studies and Analyses

VideoLinks
B2B-VideoLinks
More VideoLinks >>>