E. coli bacteria are found naturally in large quantities in our intestines. These bacteria do not normally cause disease, but there are several strains that can result in diarrhoea. In serious cases, they can also cause peritonitis and septicaemia.
The faeces of 128 Swedish infants were analysed in the studies underlying the thesis. The results show that 21% of E. coli strains in these infants' gut flora were resistant to at least one type of antibiotic. Even children who had never been given antibiotics had resistant bacterial strains in their intestines.
"This is a growing problem, and it's serious even when ordinary harmless bacteria develop resistance, as these genes can be transferred to more harmful bacteria," says microbiologist Nahid Karami.
Many had thought that resistant bacteria would disappear if the use of antibiotics were to be reduced, but the thesis shows that E. coli strains carrying resistance genes are just as good at colonising the gut for long periods as sensitive strains.
"Our research suggests that there's little cost to the bacteria from carrying a resistance gene, and this presumably means that this resistance will be retained for a long time by the bacteria in our gut flora even if we stop using antibiotics," says Karami.
Bacteria have a natural ability to absorb and transfer resistance genes to other bacteria. The study discovered two cases of such transfers between E. coli strains found simultaneously in a child's intestines. The first was in an infant who was treated with penicillin, and the second in an infant who was not treated with antibiotics.
"Our results suggest that the transfer of resistance genes in the gut flora may be very common, which makes the resistance issue much more serious, as genes can easily be transferred from bacteria in the normal flora to more harmful bacteria," says Karami.Thesis presented for the title Doctor of Medicine at the Sahlgrenska Academy, Institute of Biomedicine, Department of Infectious Medicine
Title of thesis: Antibiotic resistance and fitness of Escherichia coli in the infantile commensal microbiota
The thesis is defended.
Further information: Nahid Karami, microbiologist, tel: +46 31 342 4729, mobile: +46 70 521 4860, e-mail: email@example.com Supervisor: Associate Professor Agnes Wold, tel: +46 31 342 4617, e-mail: firstname.lastname@example.org
Elin Lindström Claessen; +46-70 829 43 03; email@example.com
Newly designed molecule binds nitrogen
23.02.2018 | Julius-Maximilians-Universität Würzburg
Atomic Design by Water
23.02.2018 | Max-Planck-Institut für Eisenforschung GmbH
A newly developed laser technology has enabled physicists in the Laboratory for Attosecond Physics (jointly run by LMU Munich and the Max Planck Institute of Quantum Optics) to generate attosecond bursts of high-energy photons of unprecedented intensity. This has made it possible to observe the interaction of multiple photons in a single such pulse with electrons in the inner orbital shell of an atom.
In order to observe the ultrafast electron motion in the inner shells of atoms with short light pulses, the pulses must not only be ultrashort, but very...
A group of researchers led by Andrea Cavalleri at the Max Planck Institute for Structure and Dynamics of Matter (MPSD) in Hamburg has demonstrated a new method enabling precise measurements of the interatomic forces that hold crystalline solids together. The paper Probing the Interatomic Potential of Solids by Strong-Field Nonlinear Phononics, published online in Nature, explains how a terahertz-frequency laser pulse can drive very large deformations of the crystal.
By measuring the highly unusual atomic trajectories under extreme electromagnetic transients, the MPSD group could reconstruct how rigid the atomic bonds are...
Quantum computers may one day solve algorithmic problems which even the biggest supercomputers today can’t manage. But how do you test a quantum computer to...
For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.
In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
15.02.2018 | Event News
13.02.2018 | Event News
12.02.2018 | Event News
23.02.2018 | Physics and Astronomy
23.02.2018 | Health and Medicine
23.02.2018 | Physics and Astronomy