Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Fatty acid catabolism higher due to polyphenol intake

15.05.2007
Polyphenols, dietary substances from vegetables, fruits and green tea, bring about a change in the energy metabolism. Dutch researcher Vincent de Boer has discovered that polyphenols increase the fatty acid breakdown in rats and influence the glucose use in fat cells.

De Boer carried out his doctoral research at RIKILT - Institute of Food Safety in Wageningen. Much research into the health effects of polyphenols is carried out in vitro. However in the body, polyphenols are quickly and easily converted into polyphenol metabolites. This research was carried out with rats to study the mechanisms and effects of a polyphenol-rich diet. Relevant polyphenol metabolites that are found in humans were also examined.

Quercetin is a polyphenol that is highly abundant in the human diet, such as onions, apples and tea. The study revealed that quercetin metabolites mainly end up in the lungs of rats. Subsequently De Boer discovered that lung cells had a greater fatty acid catabolism if the animals constantly received quercetin in their feed.

Energy regulation

... more about:
»Boer »Polyphenol »Quercetin »SIRT1 »acid »effect »metabolite

The energy-sensing protein SIRT1 is an important regulatory protein that can prolong the life span of model organisms such as yeast and fruit flies. In humans, SIRT1 is possibly involved in the regulation of energy use. The SIRT1 activity can be simulated by various polyphenols. De Boer discovered that polyphenols from green tea stimulated the activity of isolated SIRT1. The quercetin molecule also did this, but an important human quercetin metabolite had the opposite effect. Therefore in intestinal cells, quercetin had no effect on the activity of SIRT1. In experiments with fat cells, both quercetin and a quercetin metabolite were found to change the glucose use in the fat cell.

A change in the energy regulation might be an important process for the realisation of possible health effects of polyphenols in the food. This provides new starting points for further research into the molecular mechanisms of polyphenols. This will allow the health effects of polyphenols to be accurately described.

Polyphenols

Polyphenols are substances of plant origin that occur in numerous fruits and vegetables. Due to their possible health effect, polyphenols are currently sold as nutritional supplements. Yet the scientific basis for the health claims for polyphenols is mostly weak. Results from in vitro studies are often directly translated into possible beneficial health effects in humans. De Boer’s research shows that in vivo research with polyphenol metabolites is necessary to study the effects of polyphenols.

Rubicon

Vincent de Boer recently received a Rubicon fellowship from NWO for his new research into the role of mitochondrial SIRT1 analogues in aging and energy metabolism. He will carry out his research at the Department of Pathology at the Harvard Medical School in Boston.

Vincent de Boer | alfa
Further information:
http://www.hms.harvard.edu

Further reports about: Boer Polyphenol Quercetin SIRT1 acid effect metabolite

More articles from Life Sciences:

nachricht Transport of molecular motors into cilia
28.03.2017 | Aarhus University

nachricht Asian dust providing key nutrients for California's giant sequoias
28.03.2017 | University of California - Riverside

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Challenging European Research Project to Develop New Tiny Microscopes

The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.

To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Researchers shoot for success with simulations of laser pulse-material interactions

29.03.2017 | Materials Sciences

Igniting a solar flare in the corona with lower-atmosphere kindling

29.03.2017 | Physics and Astronomy

As sea level rises, much of Honolulu and Waikiki vulnerable to groundwater inundation

29.03.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>