Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Fatty acid catabolism higher due to polyphenol intake

15.05.2007
Polyphenols, dietary substances from vegetables, fruits and green tea, bring about a change in the energy metabolism. Dutch researcher Vincent de Boer has discovered that polyphenols increase the fatty acid breakdown in rats and influence the glucose use in fat cells.

De Boer carried out his doctoral research at RIKILT - Institute of Food Safety in Wageningen. Much research into the health effects of polyphenols is carried out in vitro. However in the body, polyphenols are quickly and easily converted into polyphenol metabolites. This research was carried out with rats to study the mechanisms and effects of a polyphenol-rich diet. Relevant polyphenol metabolites that are found in humans were also examined.

Quercetin is a polyphenol that is highly abundant in the human diet, such as onions, apples and tea. The study revealed that quercetin metabolites mainly end up in the lungs of rats. Subsequently De Boer discovered that lung cells had a greater fatty acid catabolism if the animals constantly received quercetin in their feed.

Energy regulation

... more about:
»Boer »Polyphenol »Quercetin »SIRT1 »acid »effect »metabolite

The energy-sensing protein SIRT1 is an important regulatory protein that can prolong the life span of model organisms such as yeast and fruit flies. In humans, SIRT1 is possibly involved in the regulation of energy use. The SIRT1 activity can be simulated by various polyphenols. De Boer discovered that polyphenols from green tea stimulated the activity of isolated SIRT1. The quercetin molecule also did this, but an important human quercetin metabolite had the opposite effect. Therefore in intestinal cells, quercetin had no effect on the activity of SIRT1. In experiments with fat cells, both quercetin and a quercetin metabolite were found to change the glucose use in the fat cell.

A change in the energy regulation might be an important process for the realisation of possible health effects of polyphenols in the food. This provides new starting points for further research into the molecular mechanisms of polyphenols. This will allow the health effects of polyphenols to be accurately described.

Polyphenols

Polyphenols are substances of plant origin that occur in numerous fruits and vegetables. Due to their possible health effect, polyphenols are currently sold as nutritional supplements. Yet the scientific basis for the health claims for polyphenols is mostly weak. Results from in vitro studies are often directly translated into possible beneficial health effects in humans. De Boer’s research shows that in vivo research with polyphenol metabolites is necessary to study the effects of polyphenols.

Rubicon

Vincent de Boer recently received a Rubicon fellowship from NWO for his new research into the role of mitochondrial SIRT1 analogues in aging and energy metabolism. He will carry out his research at the Department of Pathology at the Harvard Medical School in Boston.

Vincent de Boer | alfa
Further information:
http://www.hms.harvard.edu

Further reports about: Boer Polyphenol Quercetin SIRT1 acid effect metabolite

More articles from Life Sciences:

nachricht Single-stranded DNA and RNA origami go live
15.12.2017 | Wyss Institute for Biologically Inspired Engineering at Harvard

nachricht New antbird species discovered in Peru by LSU ornithologists
15.12.2017 | Louisiana State University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First-of-its-kind chemical oscillator offers new level of molecular control

DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.

Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...

Im Focus: Long-lived storage of a photonic qubit for worldwide teleportation

MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.

Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Engineers program tiny robots to move, think like insects

15.12.2017 | Power and Electrical Engineering

One in 5 materials chemistry papers may be wrong, study suggests

15.12.2017 | Materials Sciences

New antbird species discovered in Peru by LSU ornithologists

15.12.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>