Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Fatty acid catabolism higher due to polyphenol intake

15.05.2007
Polyphenols, dietary substances from vegetables, fruits and green tea, bring about a change in the energy metabolism. Dutch researcher Vincent de Boer has discovered that polyphenols increase the fatty acid breakdown in rats and influence the glucose use in fat cells.

De Boer carried out his doctoral research at RIKILT - Institute of Food Safety in Wageningen. Much research into the health effects of polyphenols is carried out in vitro. However in the body, polyphenols are quickly and easily converted into polyphenol metabolites. This research was carried out with rats to study the mechanisms and effects of a polyphenol-rich diet. Relevant polyphenol metabolites that are found in humans were also examined.

Quercetin is a polyphenol that is highly abundant in the human diet, such as onions, apples and tea. The study revealed that quercetin metabolites mainly end up in the lungs of rats. Subsequently De Boer discovered that lung cells had a greater fatty acid catabolism if the animals constantly received quercetin in their feed.

Energy regulation

... more about:
»Boer »Polyphenol »Quercetin »SIRT1 »acid »effect »metabolite

The energy-sensing protein SIRT1 is an important regulatory protein that can prolong the life span of model organisms such as yeast and fruit flies. In humans, SIRT1 is possibly involved in the regulation of energy use. The SIRT1 activity can be simulated by various polyphenols. De Boer discovered that polyphenols from green tea stimulated the activity of isolated SIRT1. The quercetin molecule also did this, but an important human quercetin metabolite had the opposite effect. Therefore in intestinal cells, quercetin had no effect on the activity of SIRT1. In experiments with fat cells, both quercetin and a quercetin metabolite were found to change the glucose use in the fat cell.

A change in the energy regulation might be an important process for the realisation of possible health effects of polyphenols in the food. This provides new starting points for further research into the molecular mechanisms of polyphenols. This will allow the health effects of polyphenols to be accurately described.

Polyphenols

Polyphenols are substances of plant origin that occur in numerous fruits and vegetables. Due to their possible health effect, polyphenols are currently sold as nutritional supplements. Yet the scientific basis for the health claims for polyphenols is mostly weak. Results from in vitro studies are often directly translated into possible beneficial health effects in humans. De Boer’s research shows that in vivo research with polyphenol metabolites is necessary to study the effects of polyphenols.

Rubicon

Vincent de Boer recently received a Rubicon fellowship from NWO for his new research into the role of mitochondrial SIRT1 analogues in aging and energy metabolism. He will carry out his research at the Department of Pathology at the Harvard Medical School in Boston.

Vincent de Boer | alfa
Further information:
http://www.hms.harvard.edu

Further reports about: Boer Polyphenol Quercetin SIRT1 acid effect metabolite

More articles from Life Sciences:

nachricht Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery
20.01.2017 | GSI Helmholtzzentrum für Schwerionenforschung GmbH

nachricht Seeking structure with metagenome sequences
20.01.2017 | DOE/Joint Genome Institute

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>