Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Discovery of entirely new process in cell RNA

11.05.2007
Uppsala University scientists have discovered an entirely new process in which short, tiny “antisense RNA” competes with the protein-producing ribosomes for starting sites for reading messenger RNA. These unexpected findings are being presented in the new issue of the prestigious journal Molecular Cell.

When cells grow and reproduce, they must constantly produce new proteins from their building blocks, 20 different amino acids. These proteins are put together by ribosomes, which move along messenger RNA molecules to read and translate information to the sequences of amino acids that determine the function of all of the proteins in the cell.

It was previously known that short, tiny control RNA, called antisense RNA, can stop the activity of genes by placing themselves so that “reading” of the code is impeded. It has been shown that this occurs in bacteria in that antisense RNA sets up base pairs with a certain messenger RNA (m-RNA) precisely where the ribosomes would start their reading.

“This is inhibits the reading. Ribosomes need single-strand RNA in order to start,” says Gerhart Wagner, professor of procaryote microbiology at Uppsala University.

... more about:
»Cell »RNA »amino acid »entirely »ribosome

In the Uppsala researchers’ study, an unexpected and entirely new mechanism was uncovered for this regulation of protein synthesis, which cannot be explained by a model in which antisense RNA blocks the ribosomes’ starting site on messenger RNA. In this case, instead, antisense RNA sets up base pairs far away from where the reading should start­-but still manages to stop the reading. It turns out that when a ribosome comes to a starting site that is “closed,” it attaches instead to an “open” site further along and waits for the proper site to become available.

“This is binding in stand-by, you might say. But we can show that antisense RNA competes with the ribosomes to be able to attach to this stand-by site as well. And if they get there first, then protein synthesis is prevented. This is something no one has seen before, and it provides a new picture of the innermost process of life,” says Gerhart Wagner.

Anneli Waara | alfa
Further information:
http://www.molecule.org/content/article/abstract?uid=PIIS1097276507002195

Further reports about: Cell RNA amino acid entirely ribosome

More articles from Life Sciences:

nachricht Cancer diagnosis: no more needles?
25.05.2018 | Christian-Albrechts-Universität zu Kiel

nachricht Less is more? Gene switch for healthy aging found
25.05.2018 | Leibniz-Institut für Alternsforschung - Fritz-Lipmann-Institut e.V. (FLI)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Powerful IT security for the car of the future – research alliance develops new approaches

The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.

Vehicles already offer diverse communication interfaces and more and more automated functions, such as distance and lane-keeping assist systems. At the same...

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

In focus: Climate adapted plants

25.05.2018 | Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

 
Latest News

In focus: Climate adapted plants

25.05.2018 | Event News

Flow probes from the 3D printer

25.05.2018 | Machine Engineering

Less is more? Gene switch for healthy aging found

25.05.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>