In a study published in the April 30 issue of the academic journal Chemistry & Biology, UK pharmaceutical sciences graduate student Abby Ho mentored by assistant professor Kyung-Bo Kim and ophthalmology and visual sciences assistant professor Royce Mohan describe a compound that acts directly on LMP2, a component of the immune proteasome variant that has been identified abundantly expressed in certain types of tumors, including some prostate cancers.
The compound, dubbed UK-101, inhibits LMP2 while not attacking normal cells, indicating that it could be an effective cancer treatment that does not produce the kinds of unpleasant side effects reported by many patients currently treated with broadly acting proteasome inhibitors and chemotherapeutics.
Kim and Mohan also suggest that UK-101 may be useful in treating a number of diseases in which LMP2 is involved. The researchers are particularly excited about UK-101’s potential in treating inflammatory conditions associated with arthritis, rheumatism and cardiovascular diseases.
The researchers report success in using the compound in tests in prostate cancer cells. Importantly, Kim and Mohan point out that in test using highly sensitive vascular endothelial cells obtained from blood vessels that UK-101 was found to be non toxic because they lacked expression of this LMP2 immunoproteasome target.
Dan Adkins | EurekAlert!
Polymers Based on Boron?
18.01.2018 | Julius-Maximilians-Universität Würzburg
Bioengineered soft microfibers improve T-cell production
18.01.2018 | Columbia University School of Engineering and Applied Science
What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...
For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.
Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...
At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.
No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...
Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.
Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...
The oceans are the largest global heat reservoir. As a result of man-made global warming, the temperature in the global climate system increases; around 90% of...
08.01.2018 | Event News
11.12.2017 | Event News
08.12.2017 | Event News
18.01.2018 | Medical Engineering
18.01.2018 | Ecology, The Environment and Conservation
17.01.2018 | Ecology, The Environment and Conservation