The clinical trials to test the safety of the formulation will be conducted in the UK on a group of 46 women (one-third treated with a high-dose of antibodies, one-third with a with a low-dose of antibodies and one-third with a placebo).
The three monoclonal antibodies (C2F5, C2G12 and C4E10) developed by Polymun, an Austrian-based partner of the EMPRO Consortium, have shown therapeutic effects. For the clinical trials, the antibodies will be formulated in a gel as topically applied microbicides.
“The antibodies developed by Polymun are widely used by the scientific community for research and described in many publications. In addition their unique neutralization properties, consistent quality, high purity and absence of protein additives make them valuable tools in obtaining more reliable research results,” commented Charles Kelly, EMPRO Project Coordinator and Professor at King’s College London. “That’s why we have high hopes for the results of the phase one clinical trial and that it will prove the first step in the speedy development of an effective formulation.”
The antibodies have been designed to guide the immune system’s defences towards their target by:
- directly eliminating invading agents (e.g. in mucosal surfaces)
- neutralizing infectious agents by blocking essential steps in the infective process
- activation of sterilizing immune functions (e.g. via the complement system or cytotoxic cells).
Silvia Novembre | alfa
Cancer diagnosis: no more needles?
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25.05.2018 | Leibniz-Institut für Alternsforschung - Fritz-Lipmann-Institut e.V. (FLI)
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There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
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