Spores of the harmless gut bacterium Bacillus subtilis are already taken orally as a probiotic to aid digestive health. The research programme will involve genetically engineered spores to express vaccine determinants on their coat.
Such spores are able to survive ingestion, and can therefore deliver the vaccine to the immune system of the gut and induce immunity. Spores are very stable and do not require cold storage, and the oral delivery will avoid the problems associated with needles, making this technology particularly valuable in developing countries.
The initial disease targets will be malaria and tuberculosis, which kill millions of people annually, but the spore-based approach represents a platform technology to deliver vaccines against a wide range of diseases.
David Thatcher, Chief Executive of Cobra Biomanufacturing, commented: “This consortium brings together creative science from around the world including, UK, Germany, Italy, Austria and Vietnam with the aim of applying modern genetic techniques to develop cheap effective oral vaccines. Cobra is delighted to be collaborating on this innovative project which along with Cobra’s proprietary ORT-VAC technology reinforces Cobra’s position at the forefront of oral vaccine research.”
Gemma Price | alfa
Research team of the HAW Hamburg reanimated ancestral microbe from the depth of the earth
01.03.2017 | Hochschule für Angewandte Wissenschaften Hamburg
Researchers Imitate Molecular Crowding in Cells
01.03.2017 | Universität Basel
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded after a glide flight with an Airbus A320 in ditching on the Hudson River. All 155 people on board were saved.
On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded...
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
13.02.2017 | Event News
10.02.2017 | Event News
09.02.2017 | Event News
01.03.2017 | Health and Medicine
01.03.2017 | Physics and Astronomy
01.03.2017 | Life Sciences