Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Taking heart failure to the MAT1

07.02.2007
A gene called ménage-à-trois 1, or MAT1, plays a crucial role in the function of a master switch for production of energy in the heart cell -- a finding that has important implications for understanding and maybe even treating heart failure, said researchers from Baylor College of Medicine and other institutions in a report published in today's issue of the journal Cell Metabolism.

When Dr. Michael Schneider, professor of medicine, molecular & cellular biology, and molecular physiology & biophysics at BCM, and his colleagues studied infant mice that lacked this gene in their heart muscle cells, "We found that the hearts grew normally. This was surprising, in view of some postulated functions of MAT1. But when the animals reached five weeks of age, they began to succumb to catastrophic heart failure, and all of them were dead by two months."

Using "gene chip" technology, the researchers looked for abnormal patterns of gene expression in hearts from which the MAT1 gene was deleted. They found that genes controlling energy production in cells were particularly affected and that the cells had correspondingly low levels of the proteins required for energy production. The mitochondria -- the cell's energy factories -- were defective.

Further research showed that a particular protein called peroxisome proliferator-activated receptor-1 coactivator, or PGC-1, which is a known master regulator of energy production by cells, did not function in cells that lacked MAT1. Even when the scientists artificially increased the amount of PGC-1 in the cells, its function was decreased if there was no MAT1.

... more about:
»MAT1 »PGC-1 »failure

Ultimately, the investigators proved that MAT1 binds to PGC-1 and forms a physical complex with it, providing a direct biochemical explanation for the ability of MAT1 to serve as an essential partner to PGC-1, facilitating its role in regulating cell metabolism.

In fact, two forms of PGC-1 exist — alpha and beta — both of which have been reported by other groups to be vital to the heart. Both forms of PGC-1 were shown by Schneider's team to depend highly on MAT1 and to turn on the ordinarily responsive genes for energy production in heart tissue.

"One of the problems in failing hearts is that energy production is deficient," said Schneider. "Drugs that act on the PPARs (peroxisome proliferator activated receptors) and other nuclear receptors to promote better metabolism are a very active area of study. Finding an essential partner of PGC-1 alpha and beta that enables them to switch genes on via these receptors should be helpful in that kind of work."

Ross Tomlin | EurekAlert!
Further information:
http://www.bcm.edu

Further reports about: MAT1 PGC-1 failure

More articles from Life Sciences:

nachricht The balancing act: An enzyme that links endocytosis to membrane recycling
07.12.2016 | National Centre for Biological Sciences

nachricht Transforming plant cells from generalists to specialists
07.12.2016 | Duke University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

NTU scientists build new ultrasound device using 3-D printing technology

07.12.2016 | Health and Medicine

The balancing act: An enzyme that links endocytosis to membrane recycling

07.12.2016 | Life Sciences

How to turn white fat brown

07.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>