UCF Professor Cristina Calestani was part of the Sea Urchin Genome Sequencing Group, which recently completed sequencing of the sea urchin genome and published its findings in the November issue of Science. The National Institutes of Health funded most of the nine-month project.
The genome of the purple sea urchin is composed by 814 "letters" coding for 23,300 genes.
Sea urchins are echinoderms, marine animals that originated more than 540 million years ago. The reason for the great interest in sequencing the sea urchin genome is because it shares a common ancestor with humans. Sea urchins are closer to human and vertebrates from an evolutionary perspective than other more widely studied animal models, such as fruit fly or worms. The purple sea urchin, in fact, has 7,000 genes in common with humans, including genes associated with Parkinson’s, Alzheimer’s and Huntington’s diseases and muscular dystrophy.
"Another surprise is that this spiny creature with no eyes, nose or hears has genes involved in vision, hearing and smell in humans," Calestani said. "The comparison of human genes with their corresponding ancestral sea urchin genes may give important insight on their function in humans, in the same way the study of history helps understanding the reality of our modern world."
The genome sequencing project was led by Erica Sodergren and George Weinstock at the Baylor College of Medicine-Human Genome Sequencing Center in Houston, along with Dr. Richard Gibbs, director of the Baylor center, and Drs. Eric Davidson and Andrew Cameron at the California Institute of Technology.
Of particular interest to Calestani is the way the sea urchin’s immune system works. The human immune system has two components: innate immunity, with which we are born, and acquired immunity, which is the ability to produce antibodies in response to an infection. Sea urchins only have innate immunity, and it is greatly expanded with 10 to 20 times as many genes as in human.
"Considering that sea urchins have a long life span -- some can live up to 100 years -- their immune system must be powerful," Calestani said. "Sea urchins could very well provide a new set of antibiotic and antiviral compounds to fight various infectious diseases."
The sea urchin has been used for many years as a research model to study embryonic development.
Cell development is very complicated. In order to properly regulate just one gene expression of a single-cell layered gut of the sea urchin larva, at least 14 proteins binding the DNA at 50 sites are needed, Calestani said.
"Multiply that hundreds of times and you begin to understand the level of complexity involved in human development," she added.
Using a "simple" creature like the sea urchin embryo to uncover the molecular basis underlying development offers several experimental advantages compared to the use of mice. Raising sea urchin embryos is easy and inexpensive. One female can provide up to 20 millions eggs. The embryos develop in just three days and are transparent. Also, single cells can be easily observed live in the embryos.
"If we know how these biological processes work, then we can begin to figure out how to intercede to repair and to heal," Calestani said. "It holds a lot of promise."
Calestani is continuing her work with sea urchins at UCF in Orlando by examining the development of pigment cells found in the marine creatures. Those cells also might provide some insight into human immunity to diseases.
Calestani, who teaches genetics at UCF, worked with Davidson at Caltech before arriving at UCF.
Zenaida Gonzalez Kotala | EurekAlert!
Multi-institutional collaboration uncovers how molecular machines assemble
02.12.2016 | Salk Institute
Fertilized egg cells trigger and monitor loss of sperm’s epigenetic memory
02.12.2016 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water
In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...
The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.
Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
02.12.2016 | Medical Engineering
02.12.2016 | Agricultural and Forestry Science
02.12.2016 | Physics and Astronomy