Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Protein-based tumor biomarker predicts breast-cancer survival

07.12.2006
The first and largest clinical trial of its kind confirms that a protein called p27 may be a valuable tool for predicting survival after a diagnosis of breast cancer.

The findings, by lead author Peggy Porter, M.D., of Fred Hutchinson Cancer Research Center, in collaboration with colleagues from nine other institutions, appear in the Dec. 6 issue of the Journal of the National Cancer Institute. More than a decade ago, Porter and colleagues at the Hutchinson Center identified p27, a protein that prevents cells from dividing. Since then, several population-based and clinical studies at the Hutchinson Center and elsewhere have indicated that abnormally low levels of this protein in tumor cells are associated with poor prognosis for breast and other cancers.

This link suggests that p27 may be a useful clinical biomarker, or predictor, of breast-cancer survival. However, such attempts to determine the prognostic value of p27 have been limited by the fact that the women studied have not received uniform treatment, so it has been unclear whether certain treatments may impact the strength of p27 as a predictor of outcome.

Now, for the first time, researchers have confirmed the link between low p27 expression and decreased breast-cancer survival in a large randomized, controlled clinical trial of two standard chemotherapy drugs.

... more about:
»Treatment »breast-cancer »p27 »survival »trial

"Being able to look at the impact of p27 on breast-cancer outcome in a clinical setting in which all the women were treated similarly allows us to tease out the relationship between the expression of this protein and breast-cancer mortality. Until now, we haven't been able to look at this," said Porter, a member of the Hutchinson Center's Human Biology and Public Health Sciences divisions.

The researchers found that low p27 expression is associated with poor breast-cancer prognosis, particularly among women with hormone-receptor-positive tumors, which depend on the hormones estrogen and progesterone to grow. Specifically, they found the five-year survival was 91 percent in women whose tumors had high p27 expression, as compared to a survival rate of 85 percent in women whose tumors exhibited low p27 expression. The researchers found no association between p27 expression and decreased survival among women with hormone-receptor-negative tumors.

The multicenter study involved more than 3,000 women nationwide (median age 47) with newly diagnosed moderate-risk, primary breast cancer who underwent treatment with doxorubicin and cyclophosphamide. The trial was designed to assess the effectiveness of giving the drugs together (concurrently) or one after the other (sequentially). The study was conducted through the Southwest Oncology Group, one of the largest cancer clinical trials cooperative research efforts in the United States.

Tissue samples for the study were provided by several SWOG clinical-trial groups (the Eastern Cooperative Group, North Central Cancer Treatment Group, and Cancer and Leukemia Group B). "The collaboration among these groups enabled us to gather enough data to produce statistically significant results," said Porter, whose Hutchinson Center team analyzed more than 2,000 breast-tumor samples for p27 expression. The specimens were analyzed via tissue microarray, a relatively new technique that mimics high-throughput methods originally developed for large-scale genetic analysis.

Using this method, many tumor samples can be analyzed for protein expression at once.

While the findings suggest that p27 may be a useful clinical tool for predicting breast-cancer mortality, more work needs to be done before it sees widespread use, Porter said.

"I think p27 has clinical potential, but we still need to define which patient populations are going to benefit most. Right now it looks like it may be most useful for predicting outcome and tailoring treatment in women whose tumors are hormone-receptor positive," Porter said.

Kristen Lidke Woodward | EurekAlert!
Further information:
http://www.fhcrc.org

Further reports about: Treatment breast-cancer p27 survival trial

More articles from Life Sciences:

nachricht Cryo-electron microscopy achieves unprecedented resolution using new computational methods
24.03.2017 | DOE/Lawrence Berkeley National Laboratory

nachricht How cheetahs stay fit and healthy
24.03.2017 | Forschungsverbund Berlin e.V.

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Argon is not the 'dope' for metallic hydrogen

24.03.2017 | Materials Sciences

Astronomers find unexpected, dust-obscured star formation in distant galaxy

24.03.2017 | Physics and Astronomy

Gravitational wave kicks monster black hole out of galactic core

24.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>