Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Protein-based tumor biomarker predicts breast-cancer survival

07.12.2006
The first and largest clinical trial of its kind confirms that a protein called p27 may be a valuable tool for predicting survival after a diagnosis of breast cancer.

The findings, by lead author Peggy Porter, M.D., of Fred Hutchinson Cancer Research Center, in collaboration with colleagues from nine other institutions, appear in the Dec. 6 issue of the Journal of the National Cancer Institute. More than a decade ago, Porter and colleagues at the Hutchinson Center identified p27, a protein that prevents cells from dividing. Since then, several population-based and clinical studies at the Hutchinson Center and elsewhere have indicated that abnormally low levels of this protein in tumor cells are associated with poor prognosis for breast and other cancers.

This link suggests that p27 may be a useful clinical biomarker, or predictor, of breast-cancer survival. However, such attempts to determine the prognostic value of p27 have been limited by the fact that the women studied have not received uniform treatment, so it has been unclear whether certain treatments may impact the strength of p27 as a predictor of outcome.

Now, for the first time, researchers have confirmed the link between low p27 expression and decreased breast-cancer survival in a large randomized, controlled clinical trial of two standard chemotherapy drugs.

... more about:
»Treatment »breast-cancer »p27 »survival »trial

"Being able to look at the impact of p27 on breast-cancer outcome in a clinical setting in which all the women were treated similarly allows us to tease out the relationship between the expression of this protein and breast-cancer mortality. Until now, we haven't been able to look at this," said Porter, a member of the Hutchinson Center's Human Biology and Public Health Sciences divisions.

The researchers found that low p27 expression is associated with poor breast-cancer prognosis, particularly among women with hormone-receptor-positive tumors, which depend on the hormones estrogen and progesterone to grow. Specifically, they found the five-year survival was 91 percent in women whose tumors had high p27 expression, as compared to a survival rate of 85 percent in women whose tumors exhibited low p27 expression. The researchers found no association between p27 expression and decreased survival among women with hormone-receptor-negative tumors.

The multicenter study involved more than 3,000 women nationwide (median age 47) with newly diagnosed moderate-risk, primary breast cancer who underwent treatment with doxorubicin and cyclophosphamide. The trial was designed to assess the effectiveness of giving the drugs together (concurrently) or one after the other (sequentially). The study was conducted through the Southwest Oncology Group, one of the largest cancer clinical trials cooperative research efforts in the United States.

Tissue samples for the study were provided by several SWOG clinical-trial groups (the Eastern Cooperative Group, North Central Cancer Treatment Group, and Cancer and Leukemia Group B). "The collaboration among these groups enabled us to gather enough data to produce statistically significant results," said Porter, whose Hutchinson Center team analyzed more than 2,000 breast-tumor samples for p27 expression. The specimens were analyzed via tissue microarray, a relatively new technique that mimics high-throughput methods originally developed for large-scale genetic analysis.

Using this method, many tumor samples can be analyzed for protein expression at once.

While the findings suggest that p27 may be a useful clinical tool for predicting breast-cancer mortality, more work needs to be done before it sees widespread use, Porter said.

"I think p27 has clinical potential, but we still need to define which patient populations are going to benefit most. Right now it looks like it may be most useful for predicting outcome and tailoring treatment in women whose tumors are hormone-receptor positive," Porter said.

Kristen Lidke Woodward | EurekAlert!
Further information:
http://www.fhcrc.org

Further reports about: Treatment breast-cancer p27 survival trial

More articles from Life Sciences:

nachricht Symbiotic bacteria: from hitchhiker to beetle bodyguard
28.04.2017 | Johannes Gutenberg-Universität Mainz

nachricht Nose2Brain – Better Therapy for Multiple Sclerosis
28.04.2017 | Fraunhofer-Institut für Grenzflächen- und Bioverfahrenstechnik IGB

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Fighting drug resistant tuberculosis – InfectoGnostics meets MYCO-NET² partners in Peru

28.04.2017 | Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

 
Latest News

Wireless power can drive tiny electronic devices in the GI tract

28.04.2017 | Medical Engineering

Ice cave in Transylvania yields window into region's past

28.04.2017 | Earth Sciences

Nose2Brain – Better Therapy for Multiple Sclerosis

28.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>