A unique breakthrough by researchers at Linköping University in Sweden creates new potential in medicine and biochemistry and at the same time provides a new piece of the puzzle in theories about the origins of life.
Normally, inorganic materials like silica are unwelcome in biological systems, since they disrupt the form and function of proteins.
“We wanted to reverse the thinking and try to design proteins that take on their function only after encountering an inorganic surface,” says Bengt-Harald Jonsson, professor of molecular biotechnology.
He directs the research team that is now presenting its findings in Angewandte Chemie.
The team designed a peptide (a short protein) with a specific distribution of positive charges. The peptide was mixed into a solution of spherical silica particles, about 9 nanometers (billionths of a meter) across. When the peptide was free in the solution it had no structure whatsoever, but when it connected with the negatively charged silica ball it assumed the form of a helix. The result was a complex of a silica particle and a functional protein.
When the researchers added amino acids to their peptide, the complex took on the properties of a catalyst, a function similar to that of enzymes in living cells.
The method has several possible fields of application:- recognition of organic molecules
“We know that RNA (which plays a decisive role in the transfer of information in cells) can bind with clay particles whose surfaces have negative charges. The probability of peptides with amino acids having formed well-defined structures with the clay at an early stage of development is considerably greater, since they are more diversified than RNA is,” says Bengt-Harald Jonsson.
Åke Hjelm | alfa
The birth of a new protein
20.10.2017 | University of Arizona
Building New Moss Factories
20.10.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau
University of Maryland researchers contribute to historic detection of gravitational waves and light created by event
On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...
Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.
Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....
Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).
When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...
Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.
How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...
Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.
It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...
17.10.2017 | Event News
10.10.2017 | Event News
10.10.2017 | Event News
20.10.2017 | Information Technology
20.10.2017 | Materials Sciences
20.10.2017 | Interdisciplinary Research