Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Slovenian team won the Grand prize at the international Genetically Engineered Machine (iGEM) competition at MIT

23.11.2006
A team of eight undergraduates from the University of Ljubljana in Slovenia—cheering and leaping onto MIT’s Kresge Auditorium stage in green team T-shirts--won the grand prize Sunday at the international Genetically Engineered Machine (iGEM) competition at MIT.

The group—which accepted the official BioBrick trophy--targeted a way to use engineered cells to intercept the body’s excessive response to infection, which can lead to a fatal condition called sepsis.

The goal of the 380 students on 35 university teams from around the world was to build biological systems the way a contractor would build a house—with a toolkit of standard parts.

Cells may one day be programmed to manufacture and deliver drugs or key molecules within the body, churn out fuels to run cars and heat houses, act as biosensors to detect pollutants, and a slew of as-yet unimagined functions. The MIT team, dubbed "eau d'ecoli," genetically engineered E. coli bacteria to smell like mint while it was growing and to smell like banana when it was done. The technique could potentially be used to improve the scent of other foul-smelling substances. “It’s kind of a cool thing to tell your bacteria how to smell,” said team member Veena Venkatachalam, an MIT sophomore majoring in chemistry and physics.

... more about:
»BioBrick »College »Slovenian »biological system »iGEM

The Slovenian team was one of the few to work with mammalian cells. Ljubljana microbiology student Monika Ciglic said that the team chose the more challenging and complicated mammalian cells over bacteria or viruses because of the potential rewards of developing a system that could work in the human body. Sepsis is one of the top 10 causes of death in the US, she said. But while the other teams had an available toolkit of 500 “BioBricks”—snippets of DNA that have been proven to accomplish certain tasks—the Slovenian team had to build all their BioBricks from scratch.

Information about BioBricks, and a toolkit to make and manipulate them, was provided by the Registry of Standard Biological Parts created by MIT.

The first grand prize runner up was Imperial College in London for their design of an oscillator device that was stable, had a high signal-to-noise ratio and could be easily integrated into other systems. Such a device has potential biomedical applications.

The second runner up was Princeton, for its team’s work on programming mouse embryonic stem cells to differentiate on command. The Princeton team’s project could one day create organs and tissues of choice from stem cells, which have the ability to turn into any part of the body. Other projects with potential applications included University of Edinburgh’s device to detect arsenic in well water, a problem that affects 100 million people around the world, especially in poorer nations;

The iGEM director, Randy Rettberg, principal research engineer in biological engineering, is convinced that synthetic biology based on standard part will spawn a worldwide industry based on engineering biological systems from standard parts. The possibilities for start-ups include companies that will make and catalog the individual parts, as well as companies that will exploit the technology to solve problems related to energy, the environment, medicine and more.

Drew Endy, assistant professor of biological engineering, said that it is “completely remarkable that 40 months ago, none of this was happening anywhere.” A small pilot program held during Independent Activities Period has grown into an international competition, and Endy said that as DNA synthesis becomes more common, the field will expand even more rapidly.

As with any technology, the danger of misuse exists. Perceptions of synthetic biology range from excitement to fear and mistrust. Endy said that the work is so new, it’s bound to scare some people. “A lot of people who were scaring folks in 1975 now have Nobel prizes,” he said.

Participants and prizes

In addition to Ljubljana, teams participating from other countries included those from University of Cambridge and Imperial College in England; University of Edinburgh; Swiss Federal Institute of Technology (ETH Zurich); Freiburg University; two institutes from Valencia, Spain; a Latin American team of high school and undergraduate students from Colombia; universities and centers in Mexico; Chiba University in Japan; a collaboration of students from Tokyo universities; the National Centre for Biological Sciences in Bangalore, University of Calgary, McGill University, University of Toronto and University of Waterloo,.

United States participants included Duke University, University of Arizona, University of Oklahoma, Boston University, Brown, Harvard, University of Michigan, Missouri Western State University, MIT, Princeton, Mississippi State, Davidson College, Rice, UC Berkeley, Purdue, Penn State, Prairie View A&M University, UT Austin, and UC San Francisco.

A panel of judges from industry and academia selected the winners at iGEM 2006 Jamboree. On Saturday, the teams presented overviews of projects they completed during the summer. On Sunday, awards were given on a variety of criteria:

(All recipients listed in order of first, second and third place prizes)

• Best part: Berkeley, Davidson College, Tokyo Alliance

• Best device: ETH Zurich, Penn State, Edinburgh

• Best system: MIT, Slovenia and UT Austin

• Best presentation: Missouri Western, Cambridge, MIT

• Best poster: Edinburgh, Missouri and Davidson, Cambridge

• Best documentation: Imperial College, Cambridge, Slovenia

• Best measurement and part characterization: Imperial College, Slovenia, Berkeley

• Best cooperation and collaboration: Tokyo Alliance, Davidson and Missouri, Toronto and Waterloo

• Best conquest of adversity: Calgary, Valencia, Davidson and Missouri

• Best real world application: Edinburgh, Princeton, Michigan

Honorable mention went to Latin America “for taking iGEM out of this world”; to McGill “for bringing cells together;” Oklahoma for “most likely to appear on CSI;” Duke for most ambitious; Chiba for most creative brainstorming; Rice for most-organized get-togethers; Purdue for best bridging strategy; Brown for “inventing a category of bacterial schoolyard games;” Prairie View for progress in detecting and remediating metals in soils; Bangalore for strategies for self-assembly; Harvard for “progress toward an extraordinarily difficult goal and best wiki organization;” the Mexico collaboration for “progress toward biological art;” University of Arizona for progress toward synthetic biology in three colors; University of California at San Francisco for steering e coli in new directions; Mississippi State for advancing hydrogen fuels to biodetection.

iGEM is an initiative of the MIT iCampus program, which is funded by Microsoft Corp.

(source: Massachusetts Institute of Technology's Press Release)

Brigita Pirc | alfa
Further information:
http://parts2.mit.edu/wiki/index.php/Ljubljana%2C_Slovenia_2006

Further reports about: BioBrick College Slovenian biological system iGEM

More articles from Life Sciences:

nachricht Molecular microscopy illuminates molecular motor motion
26.07.2017 | Penn State

nachricht New virus discovered in migratory bird in Rio Grande do Sul, Brazil
26.07.2017 | Fundação de Amparo à Pesquisa do Estado de São Paulo

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Carbon Nanotubes Turn Electrical Current into Light-emitting Quasi-particles

Strong light-matter coupling in these semiconducting tubes may hold the key to electrically pumped lasers

Light-matter quasi-particles can be generated electrically in semiconducting carbon nanotubes. Material scientists and physicists from Heidelberg University...

Im Focus: Flexible proximity sensor creates smart surfaces

Fraunhofer IPA has developed a proximity sensor made from silicone and carbon nanotubes (CNT) which detects objects and determines their position. The materials and printing process used mean that the sensor is extremely flexible, economical and can be used for large surfaces. Industry and research partners can use and further develop this innovation straight away.

At first glance, the proximity sensor appears to be nothing special: a thin, elastic layer of silicone onto which black square surfaces are printed, but these...

Im Focus: 3-D scanning with water

3-D shape acquisition using water displacement as the shape sensor for the reconstruction of complex objects

A global team of computer scientists and engineers have developed an innovative technique that more completely reconstructs challenging 3D objects. An ancient...

Im Focus: Manipulating Electron Spins Without Loss of Information

Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.

For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...

Im Focus: The proton precisely weighted

What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.

To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

Closing the Sustainability Circle: Protection of Food with Biobased Materials

21.07.2017 | Event News

»We are bringing Additive Manufacturing to SMEs«

19.07.2017 | Event News

 
Latest News

CCNY physicists master unexplored electron property

26.07.2017 | Physics and Astronomy

Molecular microscopy illuminates molecular motor motion

26.07.2017 | Life Sciences

Large-Mouthed Fish Was Top Predator After Mass Extinction

26.07.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>