Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Slovenian team won the Grand prize at the international Genetically Engineered Machine (iGEM) competition at MIT

23.11.2006
A team of eight undergraduates from the University of Ljubljana in Slovenia—cheering and leaping onto MIT’s Kresge Auditorium stage in green team T-shirts--won the grand prize Sunday at the international Genetically Engineered Machine (iGEM) competition at MIT.

The group—which accepted the official BioBrick trophy--targeted a way to use engineered cells to intercept the body’s excessive response to infection, which can lead to a fatal condition called sepsis.

The goal of the 380 students on 35 university teams from around the world was to build biological systems the way a contractor would build a house—with a toolkit of standard parts.

Cells may one day be programmed to manufacture and deliver drugs or key molecules within the body, churn out fuels to run cars and heat houses, act as biosensors to detect pollutants, and a slew of as-yet unimagined functions. The MIT team, dubbed "eau d'ecoli," genetically engineered E. coli bacteria to smell like mint while it was growing and to smell like banana when it was done. The technique could potentially be used to improve the scent of other foul-smelling substances. “It’s kind of a cool thing to tell your bacteria how to smell,” said team member Veena Venkatachalam, an MIT sophomore majoring in chemistry and physics.

... more about:
»BioBrick »College »Slovenian »biological system »iGEM

The Slovenian team was one of the few to work with mammalian cells. Ljubljana microbiology student Monika Ciglic said that the team chose the more challenging and complicated mammalian cells over bacteria or viruses because of the potential rewards of developing a system that could work in the human body. Sepsis is one of the top 10 causes of death in the US, she said. But while the other teams had an available toolkit of 500 “BioBricks”—snippets of DNA that have been proven to accomplish certain tasks—the Slovenian team had to build all their BioBricks from scratch.

Information about BioBricks, and a toolkit to make and manipulate them, was provided by the Registry of Standard Biological Parts created by MIT.

The first grand prize runner up was Imperial College in London for their design of an oscillator device that was stable, had a high signal-to-noise ratio and could be easily integrated into other systems. Such a device has potential biomedical applications.

The second runner up was Princeton, for its team’s work on programming mouse embryonic stem cells to differentiate on command. The Princeton team’s project could one day create organs and tissues of choice from stem cells, which have the ability to turn into any part of the body. Other projects with potential applications included University of Edinburgh’s device to detect arsenic in well water, a problem that affects 100 million people around the world, especially in poorer nations;

The iGEM director, Randy Rettberg, principal research engineer in biological engineering, is convinced that synthetic biology based on standard part will spawn a worldwide industry based on engineering biological systems from standard parts. The possibilities for start-ups include companies that will make and catalog the individual parts, as well as companies that will exploit the technology to solve problems related to energy, the environment, medicine and more.

Drew Endy, assistant professor of biological engineering, said that it is “completely remarkable that 40 months ago, none of this was happening anywhere.” A small pilot program held during Independent Activities Period has grown into an international competition, and Endy said that as DNA synthesis becomes more common, the field will expand even more rapidly.

As with any technology, the danger of misuse exists. Perceptions of synthetic biology range from excitement to fear and mistrust. Endy said that the work is so new, it’s bound to scare some people. “A lot of people who were scaring folks in 1975 now have Nobel prizes,” he said.

Participants and prizes

In addition to Ljubljana, teams participating from other countries included those from University of Cambridge and Imperial College in England; University of Edinburgh; Swiss Federal Institute of Technology (ETH Zurich); Freiburg University; two institutes from Valencia, Spain; a Latin American team of high school and undergraduate students from Colombia; universities and centers in Mexico; Chiba University in Japan; a collaboration of students from Tokyo universities; the National Centre for Biological Sciences in Bangalore, University of Calgary, McGill University, University of Toronto and University of Waterloo,.

United States participants included Duke University, University of Arizona, University of Oklahoma, Boston University, Brown, Harvard, University of Michigan, Missouri Western State University, MIT, Princeton, Mississippi State, Davidson College, Rice, UC Berkeley, Purdue, Penn State, Prairie View A&M University, UT Austin, and UC San Francisco.

A panel of judges from industry and academia selected the winners at iGEM 2006 Jamboree. On Saturday, the teams presented overviews of projects they completed during the summer. On Sunday, awards were given on a variety of criteria:

(All recipients listed in order of first, second and third place prizes)

• Best part: Berkeley, Davidson College, Tokyo Alliance

• Best device: ETH Zurich, Penn State, Edinburgh

• Best system: MIT, Slovenia and UT Austin

• Best presentation: Missouri Western, Cambridge, MIT

• Best poster: Edinburgh, Missouri and Davidson, Cambridge

• Best documentation: Imperial College, Cambridge, Slovenia

• Best measurement and part characterization: Imperial College, Slovenia, Berkeley

• Best cooperation and collaboration: Tokyo Alliance, Davidson and Missouri, Toronto and Waterloo

• Best conquest of adversity: Calgary, Valencia, Davidson and Missouri

• Best real world application: Edinburgh, Princeton, Michigan

Honorable mention went to Latin America “for taking iGEM out of this world”; to McGill “for bringing cells together;” Oklahoma for “most likely to appear on CSI;” Duke for most ambitious; Chiba for most creative brainstorming; Rice for most-organized get-togethers; Purdue for best bridging strategy; Brown for “inventing a category of bacterial schoolyard games;” Prairie View for progress in detecting and remediating metals in soils; Bangalore for strategies for self-assembly; Harvard for “progress toward an extraordinarily difficult goal and best wiki organization;” the Mexico collaboration for “progress toward biological art;” University of Arizona for progress toward synthetic biology in three colors; University of California at San Francisco for steering e coli in new directions; Mississippi State for advancing hydrogen fuels to biodetection.

iGEM is an initiative of the MIT iCampus program, which is funded by Microsoft Corp.

(source: Massachusetts Institute of Technology's Press Release)

Brigita Pirc | alfa
Further information:
http://parts2.mit.edu/wiki/index.php/Ljubljana%2C_Slovenia_2006

Further reports about: BioBrick College Slovenian biological system iGEM

More articles from Life Sciences:

nachricht Nanoparticle Exposure Can Awaken Dormant Viruses in the Lungs
16.01.2017 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt

nachricht Cholera bacteria infect more effectively with a simple twist of shape
13.01.2017 | Princeton University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

Im Focus: Bacterial Pac Man molecule snaps at sugar

Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.

The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

Water - as the underlying driver of the Earth’s carbon cycle

17.01.2017 | Earth Sciences

Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

17.01.2017 | Materials Sciences

Smart homes will “LISTEN” to your voice

17.01.2017 | Architecture and Construction

VideoLinks
B2B-VideoLinks
More VideoLinks >>>