Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Gene linked with mental illness shapes brain region

A gene variant associated with mental illness goes hand-in-hand with enlargement of a brain region that handles negative emotions, researchers at UT Southwestern Medical Center and the Central Texas Veterans Health Care System have found.

The region of the brain called the pulvinar is larger and contains more nerve cells in humans who carry the gene.

"This might indicate that the brain regions that receive input from the pulvinar are more strongly influenced in such individuals, and the pulvinar communicates with brain regions involved in negative emotional issues," said Dr. Dwight German, professor of psychiatry at UT Southwestern and senior author of a study available online and in a future issue of Biological Psychiatry.

The researchers focused on a gene related to the neurotransmitter serotonin, one of the chemical messengers that nerves use to communicate with one another. Once specific nerve cells release serotonin, a molecule called the serotonin transporter (SERT) brings it back into the cell. Thus, serotonin has only a brief influence on the target neurons. Drugs that prevent this re-uptake, such as Prozac, are frequently used to treat patients with depression.

... more about:
»SERT-s »Serotonin »nerve cells »pulvinar

The serotonin transporter gene has two forms, or variants: short, or SERT-s, and long, SERT-l. A person can have two copies of the short gene, one copy each of the short and long, or two copies of the long gene. It is estimated that about 17 percent of the population has two copies of the SERT-s gene.

People carrying two SERT-s genes are more sensitive to emotional stimuli and more likely to experience depression than people with one or no SERT-s genes.

The researchers studied brains from 49 deceased people, with and without psychiatric illnesses. The brains were sliced thinly, the size of the pulvinar measured, the number of nerve cells counted, and the variety of each individual's SERT gene analyzed.

They found that subjects carrying two SERT-s genes had pulvinars that were 20 percent larger and contained 20 percent more nerve cells – about 1.5 million more – than subjects with either one or two SERT-l genes. Whether the person had a psychiatric disorder did not affect the size of the pulvinar.

Dr. German cautioned, however, that the entire brain is not simply larger in individuals carrying two copies of the SERT-s gene. Similar studies in other areas of the brain have found that the SERT-s gene is associated with certain areas of the brain being smaller.

"The brain is wired differently in people who have depression, and probably from the point of view of treatment, we should try to identify these people as early as possible and intervene before the 'hard-wiring' gets altered," Dr. German said.

Aline McKenzie | EurekAlert!
Further information:

Further reports about: SERT-s Serotonin nerve cells pulvinar

More articles from Life Sciences:

nachricht Novel mechanisms of action discovered for the skin cancer medication Imiquimod
21.10.2016 | Technische Universität München

nachricht Second research flight into zero gravity
21.10.2016 | Universität Zürich

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Resolving the mystery of preeclampsia

21.10.2016 | Health and Medicine

Stanford researchers create new special-purpose computer that may someday save us billions

21.10.2016 | Information Technology

From ancient fossils to future cars

21.10.2016 | Materials Sciences

More VideoLinks >>>