Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Identification of a key gene required for brain neural circuit formation

An international team of scientists, lead by Dr. Frederic Charron at the IRCM, and Drs Ami Okada, Sue McConnell, and Marc Tessier-Lavigne in the USA, have made a discovery which could help treat spinal cord injuries and neurodegenerative diseases. This new finding will be published in the next issue of the prestigious scientific journal Nature.

The brain is composed of billions of neurons that must connect their axons with an appropriate set of targets to form the neuronal circuits that underlie its function. Developing axons are guided to their targets by attractive and repulsive guidance molecules. Inappropriate wiring or damage of these neuronal connections leads to severe abnormalities of the nervous system.

Three years ago, while he was a postdoctoral fellow in the laboratory of Dr. Marc Tessier-Lavigne, Dr. Charron discovered that Sonic Hedgehog (Shh) is an axonal attractant for brain and spinal cord neurons. However, the mechanism by which Shh elicited this effect remained unknown. The recent work of Dr. Charron, performed in close collaboration with Dr. Ami Okada and the teams of Drs. Sue McConnell and Marc Tessier-Lavigne, at Stanford University and Genentech, respectively, showed that Shh exerts its attractive effect through a novel receptor named Boc. Remarkably, this novel Shh receptor is absolutely required for the axon guidance role of Shh and the role of Shh in brain neural circuit formation.

"The findings of Dr. Charron and his team are of great relevance in developmental neurobiology and our understanding of normal brain development. This research could eventually have an impact on our understanding of neurodevelopmental disorders," says Dr. Rémi Quirion based in Montréal and Scientific Director of the Canadian Institutes of Health Research Institute of Neurosciences, Mental Health and Addiction. "No matter how specialized research findings may be, the knowledge we gain from them, holds the key to improved health and quality of life for Canadians and people throughout the world afflicted by neurodevelopmental disorders," adds Dr. Quirion.

... more about:
»Axon »Charron »Shh »neural »spinal

In addition to helping us understand the immense complexity underlying the wiring of the nervous system, the Dr. Charron's research will also help to identify novel strategies to promote the proper guidance and wiring into neural circuits of axons damaged by neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases, or by brain and spinal cord injuries.

This work will be published only a year after Dr. Charron established his laboratory at the Institut de recherches cliniques de Montréal (IRCM).

"Dr. Charron is one of the country's leading newly arrived neuroscientists. This research has important long-term implications for the repair of spinal cord injury: if we knew all of the molecules required to guide axons correctly during spinal cord healing, we'd know how to heal spinal cord injuries " says Dr. Rod McInnes, Scientific Director of the Canadian Institutes of Health Research Institute of Genetics. "This is beautiful research that adds another major brick to our building a complete understanding of how the spinal cord is made, and how injury of it can be treated."

Lucette Thériault | EurekAlert!
Further information:

Further reports about: Axon Charron Shh neural spinal

More articles from Life Sciences:

nachricht International team discovers novel Alzheimer's disease risk gene among Icelanders
24.10.2016 | Baylor College of Medicine

nachricht New bacteria groups, and stunning diversity, discovered underground
24.10.2016 | DOE/Lawrence Berkeley National Laboratory

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

New method increases energy density in lithium batteries

24.10.2016 | Power and Electrical Engineering

International team discovers novel Alzheimer's disease risk gene among Icelanders

24.10.2016 | Life Sciences

New bacteria groups, and stunning diversity, discovered underground

24.10.2016 | Life Sciences

More VideoLinks >>>