A study in rats published today in the open access journal BMC Biology shows that an injection of Granulocyte-Colony Stimulating Factor (G-CSF), whose function in the brain is to control the formation of neurons and counteract neurone death, reduces the size of the area affected by a stroke by a third when injected four hours after the onset of the stroke. The study also shows that regular, delayed injections of G-CSF, starting up to three days after experimental stroke, are effective in restoring motor functions in rats.
G-CSF is known to improve recovery after a stroke, and it is currently being tested for use in humans. The BMC Biology study is the first to show that G-CSF can be effective when injected this late after a stroke event.
Armin Schneider from Sygnis Bioscience AG (formerly known as Axaron Bioscience AG) in Heidelberg, Germany, and Wolf-Rüdiger Schäbitz from the Neurology department in Münster, Germany, together with colleagues from the universities of Heidelberg and Erlangen, used rat models of two different types of stroke to assess the effect of an injection of G-CSF on recovery.
The first model was used to assess the impact of G-CSF on the size of the brain area affected by the stroke, which is identified by the presence of dead neurons. In this model, the animals were injected with a single dose of G-CSF at 60µg/kg body weight four hours after the stroke. The researchers demonstrate that the size of the affected area is reduced by 34.5% in the rats that received G-CSF four hours after the stroke.
The second model was used to assess the effect of G-CSF on the functional performance of the animals. In this model, the rats were injected 10 µg/kg body weight of G-CSF, starting 24 or 72 hours after the stroke, for a period of ten days. Rats treated with G-CSF for ten days after the stroke performed significantly better in an exercise designed to test their physical abilities and coordination than rats that had been treated with placebo.
Juliette Savin | EurekAlert!
Cryo-electron microscopy achieves unprecedented resolution using new computational methods
24.03.2017 | DOE/Lawrence Berkeley National Laboratory
How cheetahs stay fit and healthy
24.03.2017 | Forschungsverbund Berlin e.V.
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
24.03.2017 | Materials Sciences
24.03.2017 | Physics and Astronomy
24.03.2017 | Physics and Astronomy