Northwestern University researchers have developed a 55,000-pen, two-dimensional array that allows them to simultaneously create 55,000 identical patterns drawn with tiny dots of molecular ink on substrates of gold or glass. Each structure is only a single molecule tall.
This advance of a patterning method called Dip-Pen Nanolithography (DPN), which was invented at Northwestern in 1999, was published online Monday (Sept. 25) by the journal Angewandte Chemie.
To demonstrate the technique's power, the researchers reproduced the face of Thomas Jefferson from a five-cent coin 55,000 times, which took only 30 minutes. Each identical nickel image is 12 micrometers wide -- about twice the diameter of a red blood cell -- and is made up of 8,773 dots, each 80 nanometers in diameter.
The parallel process paves the way for making DPN competitive with other optical and stamping lithographic methods used for patterning large areas on metal and semiconductor substrates, including silicon wafers. The advantage of DPN, which is a maskless lithography, is that it can be used to deliver many different types of inks simultaneously to a surface in any configuration one desires. Mask-based lithographies and stamping protocols are extremely limited in this regard.
"This development should lead to massively miniaturized gene chips, combinatorial libraries for screening pharmaceutically active materials and new ways of fabricating and integrating nanoscale or even molecular-scale components for electronics and computers," said Chad A. Mirkin, director of Northwestern's International Institute for Nanotechnology and George B. Rathmann Professor of Chemistry, who led the research.
"In addition, it could lead to new ways of studying biological systems at the single particle level, which is important for understanding how cancer cells and viruses work and for getting them to stop what they do," he said. "Essentially one can build an entire gene or protein chip that fits underneath a single cell."
Megan Fellman | EurekAlert!
Scientists decipher key principle behind reaction of metalloenzymes
15.01.2018 | Rheinisch-Westfälische Technische Hochschule Aachen
New method to map miniature brain circuits
15.01.2018 | The Francis Crick Institute
For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.
Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...
At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.
No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...
Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.
Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...
The oceans are the largest global heat reservoir. As a result of man-made global warming, the temperature in the global climate system increases; around 90% of...
Scientists at Helmholtz Zentrum München have discovered a mechanism that amplifies the autoimmune reaction in an early stage of pancreatic islet autoimmunity prior to the progression to clinical type 1 diabetes. If the researchers blocked the corresponding molecules, the immune system was significantly less active. The study was conducted under the auspices of the German Center for Diabetes Research (DZD) and was published in the journal ‘Science Translational Medicine’.
Type 1 diabetes is the most common metabolic disease in childhood and adolescence. In this disease, the body's own immune system attacks and destroys the...
15.01.2018 | Event News
08.01.2018 | Event News
11.12.2017 | Event News
15.01.2018 | Physics and Astronomy
15.01.2018 | Life Sciences
15.01.2018 | Life Sciences