Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Architects of the envelope: scientists discover an essential nucleus-building protein

06.09.2006
Every time a cell divides, the protective envelope that surrounds the nucleus is broken down and rebuilt into two new ones. Envelopes are highly complex structures of membranes and proteins which must be precisely reassembled for the nuclei to function. Scientists at the Institute for Research in Biomedicine (IRB) in Barcelona, the European Molecular Biology Laboratory (EMBL) in Heidelberg and the Pasteur Institute in Paris have discovered a protein that plays a crucial role in the assembly and structure of the nucleus. Their work appears in the September 5 issue of Current Biology.

The envelope acts as a barrier between the outer cell compartment, called the cytoplasm, and DNA stored in the cell nucleus. It regulates which molecules are allowed to pass back and forth between the two compartments. Most of this traffic passes through basket-shaped passageways called nuclear pores, which consist of intricately-woven proteins. “We haven't yet identified all the molecules in the nuclear envelope, and many questions remain about the process by which molecules are granted or denied passage,” says Peter Askjaer of IRB.

The new study shows that a protein called MEL-28 is a component of nuclear pores in the worm C. elegans, one of biology's most important model organisms. More importantly, it reveals that MEL-28 is one of the key architects as bits of membrane and proteins are drawn together to build new envelopes.

When scientists blocked the activity of MEL-28, they discovered that patches of membranes attached themselves to DNA but couldn't seal themselves off into a complete envelope. A step-by-step analysis showed that without the protein, other molecules are not drawn together properly as envelopes are rebuilt. The components were scrambled; pores were no longer built, and the wrong molecules were able to get access to DNA. Because MEL-28 remains attached to DNA during the entire process of cell division, the scientists believe it plays a crucial role early in the formation of the envelope.

... more about:
»DNA »Membrane »mel-28

MEL-28 has a close relative in human cells; one of the researchers’ future projects will be to examine whether this molecule plays a similar role in our own species. Oddly-shaped nuclear envelopes are seen in human genetic diseases such as progeria, a rare condition that causes affected children to age prematurely, and some types of muscular dystrophies. “Understanding how the nuclear envelope forms in the first place may eventually help us understand how changes in it can cause these diseases and potentially how they can be treated,” says Askjaer.

Sarah Sherwood | alfa
Further information:
http://www.irbbarcelona.org
http://www.irbbarcelona.org/index.php/en/news-events/irb-news-events

Further reports about: DNA Membrane mel-28

More articles from Life Sciences:

nachricht Could this protein protect people against coronary artery disease?
17.11.2017 | University of North Carolina Health Care

nachricht Microbial resident enables beetles to feed on a leafy diet
17.11.2017 | Max-Planck-Institut für chemische Ökologie

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

Im Focus: Wrinkles give heat a jolt in pillared graphene

Rice University researchers test 3-D carbon nanostructures' thermal transport abilities

Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

NASA detects solar flare pulses at Sun and Earth

17.11.2017 | Physics and Astronomy

NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures

17.11.2017 | Health and Medicine

The importance of biodiversity in forests could increase due to climate change

17.11.2017 | Studies and Analyses

VideoLinks
B2B-VideoLinks
More VideoLinks >>>