Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

MUHC researchers develop new model to identify ovarian cancer genes

16.08.2006
Researchers from the MUHC have developed a new model to identify ovarian cancer genes. This innovative research, published in the journal Oncogene, is a significant step towards improving treatment for this devastating disease that kills more than two-thirds of people diagnosed.

"Our findings now provide tangible targets for effective drug development. Up to now, there has been little in the way of treatment options for this disease, which is one of the most lethal of cancers," says Dr. Patricia Tonin, MUHC cancer geneticist and associate professor of Medicine and Human Genetics at McGill University. "This model not only allows us to identify the specific human chromosome 3 genes responsible for affecting tumour growth, but also has great potential to pinpoint genes in the entire human genome that would be most affected by this process."

"Ovarian cancer studies have shown the alteration of hundreds of genes. The challenge is to identify those genes that affect ovarian cancer from those which don't. Our model can be used to do just that, so that we can focus our attention on those genes most likely to affect tumour growth."

Tonin, along with Dr. Mario Chevrette, MUHC molecular biologist and assistant professor of Surgery at McGill University, and colleagues at the Institut du cancer de Montréal and Centre-Hospitalier de l'Universite de Montreal (CHUM), used a novel DNA transfer technique to move DNA from a non-tumour cell line to a human ovarian cancer cell line. The newly created cell line was then assessed for its ability to form tumours. Ovarian cancer cells that took up the non-tumour DNA lost their ability to produce these tumours. Subsequent genetic analyses revealed that a group of genes located on chromosome 3 genes were responsible for converting the cancer cell line into a non-tumour cell line. In addition, specific genes elsewhere in the human genome were affected in this process, some of which were novel and others never before studied in ovarian cancer.

This research was funded in part by the Canadian Institutes of Health Research (CIHR). "Too many women die of ovarian cancer each year," says Dr. Philip Branton, Scientific Director of the CIHR Institute of Cancer Research. "This is ground-breaking work. The more we can understand about what causes tumours to develop and what stimulates their growth, the greater are our chances of targeted treatments for women diagnosed with ovarian cancer."

Ovarian cancer starts in the cells of the ovaries-the egg producing reproductive organs on either side of the womb. There are three main types of ovarian cancer: epithelial, germ and stromal. This year alone 2,300 new cases of ovarian cancer will be diagnosed and approximately 1,600 women will die from the disease.

The Research Institute of the McGill University Health Centre (RI MUHC) is a world-renowned biomedical and health care hospital research centre. Located in Montreal, Quebec, the institute is the research arm of the MUHC, a university health centre affiliated with the Faculty of Medicine at McGill University. The institute supports over 500 researchers, nearly 1,000 graduate and postdoctoral students, and operates more than 300 laboratories devoted to a broad spectrum of fundamental and clinical research. The Research Institute operates at the forefront of knowledge, innovation and technology and is inextricably linked to the clinical programs of the MUHC, ensuring that patients benefit directly from the latest research-based knowledge.

The McGill University Health Centre (MUHC) is a comprehensive academic health institution with an international reputation for excellence in clinical programs, research and teaching. The MUHC is a merger of five teaching hospitals affiliated with the Faculty of Medicine at McGill University-the Montreal Children's, Montreal General, Royal Victoria, and Montreal Neurological Hospitals, as well as the Montreal Chest Institute. Building on the tradition of medical leadership of the founding hospitals, the goal of the MUHC is to provide patient care based on the most advanced knowledge in the health care field, and to contribute to the development of new knowledge.

The Canadian Institutes of Health Research (CIHR) is the Government of Canada's agency for health research. CIHR's mission is to create new scientific knowledge and to catalyze its translation into improved health, more effective health services and products, and a strengthened Canadian health care system. Composed of 13 Institutes, CIHR provides leadership and support to over 10,000 health researchers and trainees across Canada.

Ian Popple | MUHC
Further information:
http://www.cihr-irsc.gc.ca
http://www.nature.com/onc/journal/vaop/ncurrent/abs/1209821a.html
http://www.muhc.ca/research

More articles from Life Sciences:

nachricht Study shines light on brain cells that coordinate movement
26.06.2017 | University of Washington Health Sciences/UW Medicine

nachricht New insight into a central biological dogma on ion transport
26.06.2017 | Aarhus University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Study shines light on brain cells that coordinate movement

26.06.2017 | Life Sciences

Smooth propagation of spin waves using gold

26.06.2017 | Physics and Astronomy

Switchable DNA mini-machines store information

26.06.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>