In the July 28 issue of the Journal of Biological Chemistry, Roman Dziarski, Ph.D., and Dipika Gupta, Ph.D., propose that the proteins might be used to develop medications that could boost the body's impaired day-to-day response to bacteria in HIV/AIDS patients and others with compromised immune responses. The scientists announced discovery of the protein called PGLYRP – peptidoglycan recognition proteins – earlier this year.
Patients, such as those with HIV/AIDS, are susceptible to bacterial infections that are easily averted by people with healthy immune systems but are life-threatening to people with impaired systems.
Drs. Dziarski and Gupta, in their latest report, revealed many parts of the body produce these proteins, which fight disease-causing bacteria. These proteins appear to be the front line in defending the body from infection, mounting a defense long before the body's main immune system responds.
The IU School of Medicine – Northwest scientists report that various organs mount different defensive responses with PGLYRP when exposed to bacteria. The skin produces these proteins only when exposed to virulent or high numbers of bacteria.
In contrast, the liver, whose function is to continuously monitor the blood and fight acute infection, produces PGLYRP constantly. The researchers suggest that the liver's constant protein production may help fulfill the organ's preventative role as a blood filter.
Mary Hardin | EurekAlert!
Zap! Graphene is bad news for bacteria
23.05.2017 | Rice University
Discovery of an alga's 'dictionary of genes' could lead to advances in biofuels, medicine
23.05.2017 | University of California - Los Angeles
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.
In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...
Dental plaque and the viscous brown slime in drainpipes are two familiar examples of bacterial biofilms. Removing such bacterial depositions from surfaces is...
23.05.2017 | Event News
22.05.2017 | Event News
17.05.2017 | Event News
23.05.2017 | Physics and Astronomy
23.05.2017 | Life Sciences
23.05.2017 | Medical Engineering