The finance will enable Cizzle to progress its research into a potential new method of diagnosing and treating lung cancer, based on the discovery of the role that the protein Ciz 1 appears to play in triggering DNA replication and cell growth. As cancer is associated with abnormal cell growth, the Cizzle team ultimately hope to confirm that blocking the actions of this protein will prevent tumours from occurring or slow down the growth of existing tumours.
The company is based on the research of Dr Dawn Coverley, Lister Research Fellow in the School of Biology at the University of York, and her collaborator Dr Justin Ainscough. She says: “Our research shows that Ciz 1 plays a role in initiation of DNA replication, and recent evidence suggests that this role is disrupted in lung cancer cells. We aim to target the disrupted form of Ciz1 to generate a completely new and selective way of both diagnosing and treating small cell lung cancers. Current chemotherapies restrain the growth of all cells in the body and therefore have poorly tolerated side effects, but what we are trying to do is target the lung cancer cells specifically.”
Lung cancers are the second most common form of cancer in the West but are the most common cause of cancer death. Small cell lung cancers, associated with cigarette smoking, account for 25 per cent of all lung cancers. Cizzle plans to develop a diagnostic test and therapy to combat this specific cancer, filling a significant gap in this market. It is also possible that this technology may be applicable to other cancers.
Coverley, whose work in this area was supported by the Yorkshire Forward Bioscience Yorkshire Enterprise Fellowship scheme (BYEF) will become Chief Scientific Officer. Simon Ward, an experienced bioscience entrepreneur who set up Sheffield biotech company Molecular Skincare Ltd, then oversaw its merger into AIM listed York Pharma was Coverley’s mentor during her time within the BYEF programme. Ward will provide consultancy services to the company.Dr Joe Wiley, Fund Manager of the White Rose Technology Seedcorn Fund said:
Dr Joe Wiley | alfa
Fine organic particles in the atmosphere are more often solid glass beads than liquid oil droplets
21.04.2017 | Max-Planck-Institut für Chemie
Study overturns seminal research about the developing nervous system
21.04.2017 | University of California - Los Angeles Health Sciences
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
Two researchers at Heidelberg University have developed a model system that enables a better understanding of the processes in a quantum-physical experiment...
Glaciers might seem rather inhospitable environments. However, they are home to a diverse and vibrant microbial community. It’s becoming increasingly clear that they play a bigger role in the carbon cycle than previously thought.
A new study, now published in the journal Nature Geoscience, shows how microbial communities in melting glaciers contribute to the Earth’s carbon cycle, a...
20.04.2017 | Event News
18.04.2017 | Event News
03.04.2017 | Event News
21.04.2017 | Physics and Astronomy
21.04.2017 | Health and Medicine
21.04.2017 | Physics and Astronomy