"The fact that proepithelin doesn't appear to strongly promote cell proliferation, but instead promotes migration and invasion – two crucial steps leading to metastasis – suggests that it could be critical for the passage of a cancer from a noninvasive to an invasive phenotype," says Andrea Morrione, Ph.D., research assistant professor of urology at Jefferson Medical College of Thomas Jefferson University and Jefferson's Kimmel Cancer Center in Philadelphia.
In some cases, he notes, proepithelin might be used as a marker for bladder cancer. He and his colleagues report their findings July 15, 2006 in the journal Cancer Research.
Proepithelin is found in higher-than-normal levels in breast, ovarian and renal cancers, in addition to deadly brain cancers known as glioblastomas. It plays important roles in development, cell movement and tumor formation.
The American Cancer Society estimates that 61,420 new cases of bladder cancer will be found in the United States during 2006, making it the fifth most common cancer in this country. About 13,060 people will die of the disease. While it is treatable, especially if caught early, the cancer often returns and spreads to other areas of the body, and little is known about the molecular mechanisms behind its formation.
Dr. Morrione, along with a team including Renato Iozzo, M.D., professor of pathology, anatomy and cell biology, Raffaele Baffa, M.D., associate professor of urology, and Leonard Gomella, M.D., professor and chair of urology, all at Jefferson Medical College, knew that proepithelin was important in cell migration and wanted to investigate its potential role in bladder tumor formation.
In the study, using 5637 bladder cancer cells (cells from a type of bladder cancer), the group showed that proepithelin promoted migration of the bladder cancer cells and stimulated wound closure and invasion. He notes that looking at wound healing – "the ability of the cells to migrate and close gaps" – was another technique used to confirm proepithelin's role.
When they looked more closely at the molecular pathways involved in bladder cancer formation, they discovered that proepithelin turned on a common pathway called MAP kinase. Dr. Morrione believes that proepithelin will be found to have similar roles in other cancers.
He notes that one next step in the work is to verify whether or not proepithelin could be a marker in bladder tumors to use to predict metastasis. Bladder tumors are sometimes difficult to treat because of recurrence, he says. "There is a need for a non-invasive test for early detection of bladder tumors."
Steve Benowitz | EurekAlert!
Gene therapy shows promise for treating Niemann-Pick disease type C1
27.10.2016 | NIH/National Human Genome Research Institute
'Neighbor maps' reveal the genome's 3-D shape
27.10.2016 | International School of Advanced Studies (SISSA)
Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.
This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...
Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion
Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
27.10.2016 | Materials Sciences
27.10.2016 | Physics and Astronomy
27.10.2016 | Life Sciences