Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Jefferson scientists show protein key to bladder cancer spread, potential drug target

17.07.2006
By demonstrating that a protein – a growth factor called proepithelin – plays a crucial role in the spread of bladder cancer, scientists at Jefferson Medical College and Jefferson's Kimmel Cancer Center may have identified a potential target for drugs.

"The fact that proepithelin doesn't appear to strongly promote cell proliferation, but instead promotes migration and invasion – two crucial steps leading to metastasis – suggests that it could be critical for the passage of a cancer from a noninvasive to an invasive phenotype," says Andrea Morrione, Ph.D., research assistant professor of urology at Jefferson Medical College of Thomas Jefferson University and Jefferson's Kimmel Cancer Center in Philadelphia.

In some cases, he notes, proepithelin might be used as a marker for bladder cancer. He and his colleagues report their findings July 15, 2006 in the journal Cancer Research.

Proepithelin is found in higher-than-normal levels in breast, ovarian and renal cancers, in addition to deadly brain cancers known as glioblastomas. It plays important roles in development, cell movement and tumor formation.

The American Cancer Society estimates that 61,420 new cases of bladder cancer will be found in the United States during 2006, making it the fifth most common cancer in this country. About 13,060 people will die of the disease. While it is treatable, especially if caught early, the cancer often returns and spreads to other areas of the body, and little is known about the molecular mechanisms behind its formation.

Dr. Morrione, along with a team including Renato Iozzo, M.D., professor of pathology, anatomy and cell biology, Raffaele Baffa, M.D., associate professor of urology, and Leonard Gomella, M.D., professor and chair of urology, all at Jefferson Medical College, knew that proepithelin was important in cell migration and wanted to investigate its potential role in bladder tumor formation.

In the study, using 5637 bladder cancer cells (cells from a type of bladder cancer), the group showed that proepithelin promoted migration of the bladder cancer cells and stimulated wound closure and invasion. He notes that looking at wound healing – "the ability of the cells to migrate and close gaps" – was another technique used to confirm proepithelin's role.

When they looked more closely at the molecular pathways involved in bladder cancer formation, they discovered that proepithelin turned on a common pathway called MAP kinase. Dr. Morrione believes that proepithelin will be found to have similar roles in other cancers.

He notes that one next step in the work is to verify whether or not proepithelin could be a marker in bladder tumors to use to predict metastasis. Bladder tumors are sometimes difficult to treat because of recurrence, he says. "There is a need for a non-invasive test for early detection of bladder tumors."

Steve Benowitz | EurekAlert!
Further information:
http://www.jefferson.edu

More articles from Life Sciences:

nachricht Scientists enlist engineered protein to battle the MERS virus
22.05.2017 | University of Toronto

nachricht Insight into enzyme's 3-D structure could cut biofuel costs
19.05.2017 | DOE/Los Alamos National Laboratory

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

Im Focus: Using graphene to create quantum bits

In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.

In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...

Im Focus: Bacteria harness the lotus effect to protect themselves

Biofilms: Researchers find the causes of water-repelling properties

Dental plaque and the viscous brown slime in drainpipes are two familiar examples of bacterial biofilms. Removing such bacterial depositions from surfaces is...

Im Focus: Hydrogen Bonds Directly Detected for the First Time

For the first time, scientists have succeeded in studying the strength of hydrogen bonds in a single molecule using an atomic force microscope. Researchers from the University of Basel’s Swiss Nanoscience Institute network have reported the results in the journal Science Advances.

Hydrogen is the most common element in the universe and is an integral part of almost all organic compounds. Molecules and sections of macromolecules are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

Innovation 4.0: Shaping a humane fourth industrial revolution

17.05.2017 | Event News

Media accreditation opens for historic year at European Health Forum Gastein

16.05.2017 | Event News

 
Latest News

New approach to revolutionize the production of molecular hydrogen

22.05.2017 | Materials Sciences

Scientists enlist engineered protein to battle the MERS virus

22.05.2017 | Life Sciences

Experts explain origins of topographic relief on Earth, Mars and Titan

22.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>