In the absence of ERK1, ERK2 shows increased activity and it promotes both normal and Ras-dependent cell proliferation. In contrast, increased levels of ERK1 in cells significantly slow down their proliferation rate, especially when Ras oncoproteins are activated. These findings disprove the assumption that ERK1 and ERK2 have the same function and are fully interchangeable. This suggests that the mechanism controlling cell proliferation and malignancy is more complex than previously thought.
Chiara Vantaggiato, Ivan Formentini and colleagues in Riccardo Brambilla’s group, from the San Raffaele Scientific Institute in Milan, Italy, used gene targeting and RNA interference (RNAi) techniques to inhibit the MAP kinases ERK1 and ERK2 in mouse cells. Their results show that inhibiting ERK1 enhances ERK2 activity and promotes cell proliferation. In contrast, the knockdown of ERK2 almost completely abolishes cell proliferation. Mouse tumour cells expressing ERK1, but not ERK2, to higher levels than normally seen in tumour cells, grow into very small tumours when transplanted into live mice. Cells expressing only the protein Ras grow into much larger tumours and overexpressing ERK2 doesn’t affect the size of the tumours.
The authors propose that ERK1 and ERK2 are in competition to bind to other regulatory molecules in the signalling pathway. Their activities and expression levels must be finely tuned to ensure normal cell proliferation.
Juliette Savin | alfa
Nanoparticle Exposure Can Awaken Dormant Viruses in the Lungs
16.01.2017 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
Cholera bacteria infect more effectively with a simple twist of shape
13.01.2017 | Princeton University
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).
Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...
Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.
The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...
UMD, NOAA collaboration demonstrates suitability of in-orbit datasets for weather satellite calibration
"Traffic and weather, together on the hour!" blasts your local radio station, while your smartphone knows the weather halfway across the world. A network of...
Fiber-reinforced plastics (FRP) are frequently used in the aeronautic and automobile industry. However, the repair of workpieces made of these composite materials is often less profitable than exchanging the part. In order to increase the lifetime of FRP parts and to make them more eco-efficient, the Laser Zentrum Hannover e.V. (LZH) and the Apodius GmbH want to combine a new measuring device for fiber layer orientation with an innovative laser-based repair process.
Defects in FRP pieces may be production or operation-related. Whether or not repair is cost-effective depends on the geometry of the defective area, the tools...
10.01.2017 | Event News
09.01.2017 | Event News
05.01.2017 | Event News
16.01.2017 | Power and Electrical Engineering
16.01.2017 | Information Technology
16.01.2017 | Power and Electrical Engineering