In the absence of ERK1, ERK2 shows increased activity and it promotes both normal and Ras-dependent cell proliferation. In contrast, increased levels of ERK1 in cells significantly slow down their proliferation rate, especially when Ras oncoproteins are activated. These findings disprove the assumption that ERK1 and ERK2 have the same function and are fully interchangeable. This suggests that the mechanism controlling cell proliferation and malignancy is more complex than previously thought.
Chiara Vantaggiato, Ivan Formentini and colleagues in Riccardo Brambilla’s group, from the San Raffaele Scientific Institute in Milan, Italy, used gene targeting and RNA interference (RNAi) techniques to inhibit the MAP kinases ERK1 and ERK2 in mouse cells. Their results show that inhibiting ERK1 enhances ERK2 activity and promotes cell proliferation. In contrast, the knockdown of ERK2 almost completely abolishes cell proliferation. Mouse tumour cells expressing ERK1, but not ERK2, to higher levels than normally seen in tumour cells, grow into very small tumours when transplanted into live mice. Cells expressing only the protein Ras grow into much larger tumours and overexpressing ERK2 doesn’t affect the size of the tumours.
The authors propose that ERK1 and ERK2 are in competition to bind to other regulatory molecules in the signalling pathway. Their activities and expression levels must be finely tuned to ensure normal cell proliferation.
Juliette Savin | alfa
Molecular Force Sensors
20.09.2017 | Max-Planck-Institut für Biochemie
Foster tadpoles trigger parental instinct in poison frogs
20.09.2017 | Veterinärmedizinische Universität Wien
Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...
Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!
When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...
For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.
Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...
MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems Holding GmbH about commercial use of a multi-well tissue plate for automated and reliable tissue engineering & drug testing.
MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems...
Pathogenic bacteria are becoming resistant to common antibiotics to an ever increasing degree. One of the most difficult germs is Pseudomonas aeruginosa, a...
19.09.2017 | Event News
12.09.2017 | Event News
06.09.2017 | Event News
20.09.2017 | Life Sciences
20.09.2017 | Power and Electrical Engineering
20.09.2017 | Physics and Astronomy