In a study published today in the open access journal Journal of Biology, researchers manually curated the entire literature for genetic and physical protein interactions in the yeast Saccharomyces cerevisiae, an important model system for human cells. The database enabled better predictions of gene functions and protein interactions than all previous data collections combined.
Mike Tyers from the Samuel Lunenfeld Research Institute of Mount Sinai Hospital in Toronto, Canada and colleagues from other institutions in Canada and the USA, read over 30,000 publications on S. cerevisiae and recorded over 22,000 protein interactions and over 11,000 genetic interactions. Surprisingly, Tyers and colleagues found less than 20% overlap between their literature dataset and the datasets generated using high-throughput methods for interaction detection, indicating that many more interactions are likely to be discovered.
Tyers and colleagues’ database will enable researchers to gain further insight into individual gene functions and biological network features in yeast, and by extension other species including humans. Their study also shows that it is possible to search and sort a large amount of existing knowledge from the literature within a relatively short time frame. This approach could be applied to other organisms, from E. Coli to humans.
The literature interaction dataset is publicly available at the BioGRID database (http://thebiogrid.org/) and at the Saccharomyces Genome Database (http://www.yeastgenome.org/).
The birth of a new protein
20.10.2017 | University of Arizona
Building New Moss Factories
20.10.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau
University of Maryland researchers contribute to historic detection of gravitational waves and light created by event
On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...
Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.
Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....
Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).
When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...
Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.
How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...
Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.
It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...
17.10.2017 | Event News
10.10.2017 | Event News
10.10.2017 | Event News
20.10.2017 | Information Technology
20.10.2017 | Materials Sciences
20.10.2017 | Interdisciplinary Research