First comprehensive literature-derived database of yeast interactions
Researchers have built the first comprehensive manually-generated, literature-based, database of genetic and protein interactions. The database, which doubles the amount of information available on interaction networks in the yeast Saccharomyces cerevisiae, will be a useful resource for both the yeast and the systems biology community.
In a study published today in the open access journal Journal of Biology, researchers manually curated the entire literature for genetic and physical protein interactions in the yeast Saccharomyces cerevisiae, an important model system for human cells. The database enabled better predictions of gene functions and protein interactions than all previous data collections combined.
Mike Tyers from the Samuel Lunenfeld Research Institute of Mount Sinai Hospital in Toronto, Canada and colleagues from other institutions in Canada and the USA, read over 30,000 publications on S. cerevisiae and recorded over 22,000 protein interactions and over 11,000 genetic interactions. Surprisingly, Tyers and colleagues found less than 20% overlap between their literature dataset and the datasets generated using high-throughput methods for interaction detection, indicating that many more interactions are likely to be discovered.
Tyers and colleagues’ database will enable researchers to gain further insight into individual gene functions and biological network features in yeast, and by extension other species including humans. Their study also shows that it is possible to search and sort a large amount of existing knowledge from the literature within a relatively short time frame. This approach could be applied to other organisms, from E. Coli to humans.
The literature interaction dataset is publicly available at the BioGRID database (http://thebiogrid.org/) and at the Saccharomyces Genome Database (http://www.yeastgenome.org/).
Juliette Savin | alfa
The most recent press releases about innovation >>>
Die letzten 5 Focus-News des innovations-reports im Überblick:
An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.
Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...
Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.
Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...
Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.
As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...
Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.
With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...
Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine
Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...