Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Aberrant chromosomes uncovered in autistic children

22.05.2006
One extra chromosome, one damaged chromosome, or pieces of chromosomes missing. Eight children with four different disorders with autistic features all had one such aberration in their genes. This is shown in a dissertation from the Sahlgrenska Academy at Göteborg University in Sweden.

The children in the study had Asperger’s syndrome, infantile autism, ADHD, and Rett’s syndrome. These are so-called autism spectrum disorders that all involve some form of contact disturbance. The cause of these diseases is not known.

“Both heredity and environment play a role. I believe it’s a matter of several genes working together, and if one chromosome is damaged, there may be genes in that chromosome that have been damaged or are missing,” says research Tonnie Johannesson.

It is not known precisely which genes cause the disorders, but the dissertation provides an indication of where these genes might be situated.

“It’s as if we haven’t found the needle in the haystack yet, but now we know what haystack to look in,” says Tonnie Johannesson.

The study shows that two boys with Asperger’s syndrome had nearly identical aberrations in a chromosome. On chromosome 17, both had a break in almost exactly the same place.

“It is remarkable to find such a similarity between two unrelated patients with the same disorder,” says Tonnie Johannesson.

Following in-depth analysis, Tonnie Johannesson managed to find the faulty gene in one of the boys. The study shows that the damaged gene is of importance to the brain, but it is unclear precisely what role it plays in brain development.

Infantile autism is a form of disease that expresses itself during the child’s first year. The dissertation shows that four unrelated boys who have the disorder all had a small extra chromosome. The fifteenth pair consisted of three chromosomes instead of two.

“Genes are presumably the cause of this disorder, but we still don’t know which ones they are,” says Tonnie Johannesson.

In a mildly mentally retarded boy diagnosed with ADHD the chromosomes had changed places with each other. Three of the chromosomes had been switched around, but all the chromosome pieces seemed to be there. On the other hand, a girl with a disease resembling Rett’s syndrome proved to be lacking a piece of a chromosome in the third pair.

Elin Lindström | alfa
Further information:
http://www.sahlgrenska.gu.se

More articles from Life Sciences:

nachricht One step closer to reality
20.04.2018 | Max-Planck-Institut für Entwicklungsbiologie

nachricht The dark side of cichlid fish: from cannibal to caregiver
20.04.2018 | Veterinärmedizinische Universität Wien

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Spider silk key to new bone-fixing composite

University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.

Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.

Im Focus: Writing and deleting magnets with lasers

Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.

Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...

Im Focus: Gamma-ray flashes from plasma filaments

Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.

The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...

Im Focus: Basel researchers succeed in cultivating cartilage from stem cells

Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.

Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...

Im Focus: Like a wedge in a hinge

Researchers lay groundwork to tailor drugs for new targets in cancer therapy

In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

IWOLIA: A conference bringing together German Industrie 4.0 and French Industrie du Futur

09.04.2018 | Event News

 
Latest News

Magnetic nano-imaging on a table top

20.04.2018 | Physics and Astronomy

Start of work for the world's largest electric truck

20.04.2018 | Interdisciplinary Research

Atoms may hum a tune from grand cosmic symphony

20.04.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>