Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Aberrant chromosomes uncovered in autistic children

22.05.2006
One extra chromosome, one damaged chromosome, or pieces of chromosomes missing. Eight children with four different disorders with autistic features all had one such aberration in their genes. This is shown in a dissertation from the Sahlgrenska Academy at Göteborg University in Sweden.

The children in the study had Asperger’s syndrome, infantile autism, ADHD, and Rett’s syndrome. These are so-called autism spectrum disorders that all involve some form of contact disturbance. The cause of these diseases is not known.

“Both heredity and environment play a role. I believe it’s a matter of several genes working together, and if one chromosome is damaged, there may be genes in that chromosome that have been damaged or are missing,” says research Tonnie Johannesson.

It is not known precisely which genes cause the disorders, but the dissertation provides an indication of where these genes might be situated.

“It’s as if we haven’t found the needle in the haystack yet, but now we know what haystack to look in,” says Tonnie Johannesson.

The study shows that two boys with Asperger’s syndrome had nearly identical aberrations in a chromosome. On chromosome 17, both had a break in almost exactly the same place.

“It is remarkable to find such a similarity between two unrelated patients with the same disorder,” says Tonnie Johannesson.

Following in-depth analysis, Tonnie Johannesson managed to find the faulty gene in one of the boys. The study shows that the damaged gene is of importance to the brain, but it is unclear precisely what role it plays in brain development.

Infantile autism is a form of disease that expresses itself during the child’s first year. The dissertation shows that four unrelated boys who have the disorder all had a small extra chromosome. The fifteenth pair consisted of three chromosomes instead of two.

“Genes are presumably the cause of this disorder, but we still don’t know which ones they are,” says Tonnie Johannesson.

In a mildly mentally retarded boy diagnosed with ADHD the chromosomes had changed places with each other. Three of the chromosomes had been switched around, but all the chromosome pieces seemed to be there. On the other hand, a girl with a disease resembling Rett’s syndrome proved to be lacking a piece of a chromosome in the third pair.

Elin Lindström | alfa
Further information:
http://www.sahlgrenska.gu.se

More articles from Life Sciences:

nachricht Scientists spin artificial silk from whey protein
24.01.2017 | Deutsches Elektronen-Synchrotron DESY

nachricht Choreographing the microRNA-target dance
24.01.2017 | UT Southwestern Medical Center

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Scientists spin artificial silk from whey protein

X-ray study throws light on key process for production

A Swedish-German team of researchers has cleared up a key process for the artificial production of silk. With the help of the intense X-rays from DESY's...

Im Focus: Quantum optical sensor for the first time tested in space – with a laser system from Berlin

For the first time ever, a cloud of ultra-cold atoms has been successfully created in space on board of a sounding rocket. The MAIUS mission demonstrates that quantum optical sensors can be operated even in harsh environments like space – a prerequi-site for finding answers to the most challenging questions of fundamental physics and an important innovation driver for everyday applications.

According to Albert Einstein's Equivalence Principle, all bodies are accelerated at the same rate by the Earth's gravity, regardless of their properties. This...

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Breaking the optical bandwidth record of stable pulsed lasers

24.01.2017 | Physics and Astronomy

Choreographing the microRNA-target dance

24.01.2017 | Life Sciences

Spanish scientists create a 3-D bioprinter to print human skin

24.01.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>