Research over the past several years has demonstrated the adverse effects of industrial pollutants in water and sediment on the health of fish in the lower Duwamish River. The Duwamish flows through an industrialized section of south Seattle, Wash., and in 2001 a section of the lower river was added to the Environmental Protection Agency’s Superfund list because of contaminants including polychlorinated biphenyls (PCBs), polycyclic aromatic hydrocarbons (PAHs), mercury and other metals, and phthalates. In previous research on Duwamish fish, PNRI used an infrared spectroscopy method to document DNA damage in the gills of English sole.
In a new joint paper, the researchers report on several biomarkers, including pollution-induced P450 enzyme changes, and on infrared spectral analysis of DNA and measurements of specific modifications to DNA from fish gills and livers using liquid and gas chromatography combined with mass spectrometry (LC/MS,GC/MS). Precision chemical analysis techniques at NIST allowed the researchers to identify and measure damage to adenine and guanine, specific chemical components or bases of DNA, at extraordinarily low levels--five lesions out of a 100 million bases in one case. The results correlated well with earlier research and revealed similar damage to liver DNA (more likely tied to the fish’s food) and gill DNA (more probably reflecting pollutants in water).
The results suggest that these DNA lesions, and others like them, can be used as very sensitive biomarkers to provide a direct measure of the impact of contaminants on fish populations. Moreover, since natural DNA repair processes may gradually reverse the damage in the absence of further insults, these biomarkers also might be used to help assess the efficacy of pollution remediation efforts. The work was funded in part by the National Institute of Environmental Health Sciences (NIH).
Michael Baum | EurekAlert!
Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery
20.01.2017 | GSI Helmholtzzentrum für Schwerionenforschung GmbH
Seeking structure with metagenome sequences
20.01.2017 | DOE/Joint Genome Institute
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
20.01.2017 | Awards Funding
20.01.2017 | Materials Sciences
20.01.2017 | Life Sciences