Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Novel stem cell technology develops a new cell for repairing spinal cord injuries

27.04.2006
Researchers have identified a new way to promote recovery after spinal cord injury with an advance in stem-cell technology. A study conducted by members of the New York State Center of Research Excellence in Spinal Cord Injury and published today in the open access journal Journal of Biology reveals that rats recover from spinal cord injury following transplantation with immature support cells of the central nervous system generated from stem cells.

Transplanting immature support cells called astrocytes, which were first generated in tissue culture from stem cell-like cells called glial restricted precursors, resulted in much better outcomes for spinal cord repair than just transplanting stem cells alone. This result challenges current ideas of how to use stem cells to promote tissue repair.

The research team led by Stephen Davies from Baylor College of Medicine, Houston, USA and colleagues from the University of Rochester Medical Center, New York, USA took embryonic glial precursor cells and induced them to differentiate in culture into a specific type of embryonic astrocyte known to be highly supportive of nerve fibre growth. They hoped these cells would have the repair capabilities of the embryonic spinal cord, which is lost in adults. Davies et al. transplanted these cells into cuts in the spinal cord of adult rats and measured the growth of nerve fibres by labelling them with a dye. They then compared healing and recovery in these rats with the recovery in spinal cord injured rats that received either undifferentiated glial precursor cells or no treatment at all.

Davies et al.’s results show that transplants of the precursor-derived astrocytes promoted the rapid growth of 40% of sensory nerve fibres across the cuts. The transplanted cells also suppressed the formation of scar tissue and aligned damaged tissue at the injury site. Furthermore, neurons in the brain that normally degenerate if their nerve fibres are severed in the spinal cord, were rescued when their cut nerve fibres interacted with the astrocytes transplanted into spinal cord injuries. In contrast, transplanted precursor cells failed to suppress scar formation or promote the growth of any nerve fibres across the injury site. Importantly, in a sensitive test of limb placement during walking, rats that received the astrocyte transplants recovered and were able to walk normally within two weeks, whereas the other rats that received undifferentiated precursor cells did not recover at all and still had difficulties with walking four weeks after the surgery.

These studies make important advances in both stem cell technology and identification of the right cell types for repairing the injured adult nervous system.

Juliette Savin | alfa
Further information:
http://www.biomedcentral.com

More articles from Life Sciences:

nachricht The birth of a new protein
20.10.2017 | University of Arizona

nachricht Building New Moss Factories
20.10.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Terahertz spectroscopy goes nano

20.10.2017 | Information Technology

Strange but true: Turning a material upside down can sometimes make it softer

20.10.2017 | Materials Sciences

NRL clarifies valley polarization for electronic and optoelectronic technologies

20.10.2017 | Interdisciplinary Research

VideoLinks
B2B-VideoLinks
More VideoLinks >>>