Biologists seeking elusive proof of natural selection at the single-gene level have a powerful new tool at their disposal. Chris Toomajian, postdoctoral researcher in molecular and computational biology in the USC College of Letters, Arts and Sciences, led a group that sought to replace the standard neutral model, a common but unrealistic test for natural selection, with a statistical method based on hard genomic data.
The group’s research will be published online April 25 by Public Library of Science. "Do we now have enough data to see the standard neutral model wasn’t appropriate?" Toomajian asked. "We know something more now about how the population has been structured."
The standard neutral model makes improbable assumptions about population structure, such as assigning each individual an equal chance of reproducing.
Co-author Magnus Nordborg, associate professor of molecular and computational biology in USC College, predicted that earlier research would need to be revisited because the model makes it too easy to infer selection at any given gene. "Once you start looking at enough cases then you realize that, oops, it’s all under selection. I think a lot of that research is going to end up in the trash can," Nordborg said.
The group’s method can be applied to any organism, including humans. The PLoS paper focused on the weed Arabidopsis thaliana, and in particular on the FRIGIDA (FRI) gene, known to influence flowering time. A. thaliana was once a plant that bloomed annually. But two versions of FRI that appeared thousands of years ago enabled the plant to flower year-round, helping it out-compete other plants.
Toomajian and his group showed that these two versions, also called gene variants, are too common to have spread solely by chance. "We’ve shown that for one gene with an important role in that [flowering] process, there’s good evidence that there’s natural selection changing the behavior of the plants," Toomajian said. Why the variants were selected remains unclear, though some have suggested that the plant evolved under pressure from the spread of agriculture. Toomajian’s group identified the gene variants through a comparison of 96 plants over 1,102 short fragments of the genome.
Each variant was assigned a score based on the similarity of two plants around the FRI gene relative to their similarity at other regions in the genome. The higher the score, the less likely it is that a variant could have arisen and spread randomly. The scoring formula accounts for the greater similarity expected in related plants.
Nordborg said that while natural selection is well documented at the whole-organism level, researchers consider biochemical proof of selection "the Holy Grail" of population genetics. "What has proven very difficult is to connect specific molecular changes to selection," Nordborg said. The PLoS paper, along with other recent studies based on intrinsic genomic comparisons, brings biology closer to this goal.
Carl Marziali | EurekAlert!
Building a brain, cell by cell: Researchers make a mini neuron network (of two)
23.05.2018 | Institute of Industrial Science, The University of Tokyo
Research reveals how order first appears in liquid crystals
23.05.2018 | Brown University
At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...
There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.
The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...
02.05.2018 | Event News
13.04.2018 | Event News
12.04.2018 | Event News
23.05.2018 | Life Sciences
23.05.2018 | Life Sciences
23.05.2018 | Physics and Astronomy