Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Nature’s strongest glue could be used as a medical adhesive

11.04.2006
A bacterium that lives in rivers, streams and human aqueducts uses nature’s strongest glue to stay in one place, according to new research by Indiana University Bloomington and Brown University scientists reported in next week’s (April 11) Proceedings of the National Academy of Sciences.

The scientists found they had to apply a force of about 1 micronewton to remove a single Caulobacter crescentus from a glass pipette. Because C. crescentus is so small, the pulling force of 1 micronewton generates a huge stress of 70 newtons per square millimeter. That stress, which the bacterial adhesions could sometimes withstand, is equivalent to five tons per square inch -- three or four cars balanced atop a quarter. By contrast, commercial "super" glue breaks when a shear force of 18 to 28 newtons per square millimeter is applied.


Caulobacter crescentus affixes itself to solid objects with its stalk and holdfast. Here, two sessile "stalk" cells (bottom) spawn mobile "swarmer" clones of themselves (top).

Hypothetically, C. crescentus’s glue could be mass produced and used to coat surfaces for medical and engineering purposes.

"There are obvious applications since this adhesive works on wet surfaces," said IU Bloomington bacteriologist Yves Brun, who co-led the study with Brown University physicist Jay Tang. "One possibility would be as a biodegradable surgical adhesive."

C. crescentus affixes itself to rocks and the insides of water pipes via a long, slender stalk. At the end of the stalk is a holdfast dotted with polysaccharides (chains of sugar molecules). The scientists show in the PNAS paper that these sugars are the source of C. crescentus’s tenacity. It is presumed these sugars are attached to holdfast proteins, but this has not yet been confirmed. One thing is certain -- the polysaccharides are sticky.

"The challenge will be to produce large quantities of this glue without it sticking to everything that is used to produce it," Brun said. "Using special mutants, we can isolate the glue on glass surfaces. We tried washing the glue off. It didn’t work."

The scientists allowed C. crescentus to attach itself to the side of a thin, flexible glass pipette. They used a micromanipulator to trap the cell portion of the bacterium and pull it directly away from the pipette, measuring the force of strain. In 14 trials, the scientists found they had to apply a force of 0.11 to 2.26 micronewtons per cell before the bacterium detached.

C. crescentus has evolved an ability to live in extremely nutrient-poor conditions, which explains its existence as a common fixture in tap water. Because it exists in tap water at low concentrations and produces no human toxins, C. crescentus poses no threat to human health.

Engineer L. Ben Freund wrote the model used to perform complex mathematical analyses of experimental forces. Peter Tsang and Guanglai Li of Brown University performed experiments and analyzed data. The research was funded by grants from the National Science Foundation and the National Institute of General Medical Sciences (National Institutes of Health).

David Bricker | EurekAlert!
Further information:
http://www.indiana.edu

More articles from Life Sciences:

nachricht Link Discovered between Immune System, Brain Structure and Memory
26.04.2017 | Universität Basel

nachricht Researchers develop eco-friendly, 4-in-1 catalyst
25.04.2017 | Brown University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

Scientist invents way to trigger artificial photosynthesis to clean air

26.04.2017 | Materials Sciences

Ammonium nitrogen input increases the synthesis of anticarcinogenic compounds in broccoli

26.04.2017 | Agricultural and Forestry Science

SwRI-led team discovers lull in Mars' giant impact history

26.04.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>