Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Hepatitis C therapy: Inhibiting newly discovered microDNA molecule

06.04.2006
Reduces virus RNA abundance

Last fall Dr. Peter Sarnow and a team of Stanford University scientists reported that the hepatitis C virus needs a specific microRNA, named miR-122, in order to replicate in cultured liver cells. When the scientists inactivated the microRNA, the amount of hepatitis C virus RNA was reduced by approximately 80 percent. The discovery was widely heralded for its potential to develop new antiviral agents against hepatitis C, the most common blood-borne viral infection in the United States, affecting more than 2.5 million Americans and a staggering 170 million people worldwide. The best treatment regimens now available are difficult, expensive, laden with serious side effects and effective in only half the cases.

Dr. Sarnow discusses the most recent findings in this work on April 5 at Experimental Biology 2006 in San Francisco. His presentation is part of the scientific program of the American Society for Biochemistry and Molecular Biology.

MicroRNAs, or miRNAs for short, are small RNA molecules that regulate genes in many plant and animal species. Although miRNAs were not discovered until the mid-1990, a growing number of studies suggest that over 300 human genes encode microRNAs and that these microRNAs may control gene expression for as much as a third of the human genome, acting as key regulators of processes as diverse as early development, cell proliferation and cell death, and cell differentiation. Some miRNAs are located throughout the body, while others are found only in specific tissue. The miRNA whose surprising new role was discovered by Dr. Sarnow and his colleagues is located only in the liver. The Sarnow team found that miR-122 binds to a specific noncoding binding region in virus, called target 5’ NCR. This is the first example of an animal RNA that interacts with its target 5’ NCR, and opens an interesting possibility that other viral 5’ NCRs are similarly targeted by different miRNAs.

Sarah Goodwin | EurekAlert!
Further information:
http://www.faseb.org

More articles from Life Sciences:

nachricht A Map of the Cell’s Power Station
18.08.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau

nachricht On the way to developing a new active ingredient against chronic infections
21.08.2017 | Deutsches Zentrum für Infektionsforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

Heating quantum matter: A novel view on topology

22.08.2017 | Physics and Astronomy

Stretchable biofuel cells extract energy from sweat to power wearable devices

22.08.2017 | Power and Electrical Engineering

New technique to treating mitral valve diseases: First patient data

22.08.2017 | Medical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>