Anti-malarial drugs are most effective in people with lupus who are genetically predisposed to high levels of tumour necrosis factor alpha and low levels of the cytokine IL-10. A study published today in the journal Arthritis Research & Therapy reveals that anti-malarial drugs, widely used to treat systemic lupus erythematosus (SLE), bring serum levels of tumour necrosis factor alpha (TNF-alpha) back to normal in SLE patients. The research shows that these drugs are more effective in patients who have two specific genetic variations (polymorphisms) on the TNF-alpha and IL-10 genes that predispose them to abnormally high levels of TNF-alpha and low levels of the cytokine IL-10. This finding may have important clinical applications through the identification of lupus patients who are the most likely to benefit from anti-malarial therapy.
Patricia Lopez, from the University of Oviedo in Spain and colleagues from the Hospital Universitario Central de Asturias in Oviedo matched 192 SLE patients with 343 healthy individuals to act as controls. The researchers genotyped both patients and controls for two specific polymorphisms on the TNF-alpha and IL-10 genes. Lopez et al. then measured TNF-alpha serum levels in 171 of the SLE patients and 215 of the controls. The patients were asked precise questions regarding any treatment received before the study.
Lopez et al.s results show that, as expected, average TNF-alpha serum levels were higher in the population of SLE patients (33.57pg/ml) than in the group of controls (19.66 pg/ml). However, patients who had been taking anti-malarial drugs for at least three months before the study had serum levels of TNF-alpha (16.64 pg/ml) similar to those of controls. Patients who had not been taking the drugs before the study had much higher levels of TNF-alpha (60.78 pg/ml).
Juliette Savin | EurekAlert!
Cryo-electron microscopy achieves unprecedented resolution using new computational methods
24.03.2017 | DOE/Lawrence Berkeley National Laboratory
How cheetahs stay fit and healthy
24.03.2017 | Forschungsverbund Berlin e.V.
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
24.03.2017 | Materials Sciences
24.03.2017 | Physics and Astronomy
24.03.2017 | Physics and Astronomy