Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Aston Academy Investigates Sight Threatening Disease

27.01.2006


Aston Academy of Life Sciences, the clinical research hospital of Aston University, has recently been commissioned to assess the efficacy and safety of a specialist drug, Posurdex (Allergan Ltd, UK), which is used in the treatment of patients who suffer from a sight threatening condition, called macular oedema.



It is estimated that the condition, which is caused by occlusion (blockage) of the central or branch retinal veins in the eye, affects over two and a half million people worldwide, with over 245,000 people in the UK being affected, most of whom are untreatable. This phase III clinical trial commissioned at the Academy and other sites in the UK, Europe and Worldwide offers the hope of significant improvement in vision for those who suffer with the condition.

The disease affects the macula, a tiny oval area at the centre of the retina which is responsible for "central vision" and is important for tasks that require detailed vision, such as reading and driving. The disease process involves the build up of fluid causing swelling of the macula which can result in severe visual disabilities and blindness particularly among people with diabetes.


The condition is also specifically associated with other visual conditions including diabetic retinopathy, retinal vein occlusion and uveitis (the inflammation of the part of the eye containing the iris, cillary body and choroids).

Once implanted, Posurdex releases dexamethasone to the targeted disease site at the back of the eye. Dexamethasone, a corticosteroid, reduces the macula swelling.

In relation to this new trial the Academy hosted a mini convention on 25 January, which was attended by 18 of the UK’s leading consultant retinal specialists and a number of research scientists from Aston and other Universities. They discussed the use of Anti-VEGF (Vascular endothelial growth factor) for the treatment of age-related-macular degeneration (AMD) through injections into the back of the eye.

Managing Director of the Academy and a Reader in the School of Life & Health Sciences at Aston University, Dr Sarah Hosking said: "These new interventions for AMD mark the start of an exciting new era for the potential treatment of the many patients with this debilitating and often blinding condition. The Academy will act as a hub of clinical research activity at the University, involving some of the UK’s leading retinal specialists. This Phase III clinical trial is the first step, however studies are likely to extend into the development of other related treatments drawing on expertise from our School of Pharmacy and expert ophthalmologists. Patients will be referred to the Academy from all over the Midlands by partnering ophthalmologists".

Aston Academy of Life Sciences also offers a range of ophthalmology services including cataract and refractive surgery, as well as MRI scanning to patients. Patients can be referred by doctors or optometrists or can simply refer themselves.

Hannah Brookes | alfa
Further information:
http://www.astonacademy.co.uk

More articles from Life Sciences:

nachricht Nanoparticle Exposure Can Awaken Dormant Viruses in the Lungs
16.01.2017 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt

nachricht Cholera bacteria infect more effectively with a simple twist of shape
13.01.2017 | Princeton University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

Im Focus: Bacterial Pac Man molecule snaps at sugar

Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.

The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

Water - as the underlying driver of the Earth’s carbon cycle

17.01.2017 | Earth Sciences

Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

17.01.2017 | Materials Sciences

Smart homes will “LISTEN” to your voice

17.01.2017 | Architecture and Construction

VideoLinks
B2B-VideoLinks
More VideoLinks >>>