A group of Northwestern University researchers is developing a novel gene therapy aimed at selectively turning off one of the genes involved in the development of Parkinsons disease.
The gene therapy, described in the January online issue of the journal Experimental Neurology, was designed by Martha Bohn and her laboratory group at Northwestern University Feinberg School of Medicine.
Bohn is Medical Research Council Professor and director of the neurobiology program at Childrens Memorial Research Center and professor of pediatrics and of molecular pharmacology and biological chemistry at the Feinberg School. The gene technique the Bohn lab developed removes a protein known as alpha-synuclein from the diseased dopamine-producing neurons that die in Parkinsons disease. Alpha-synuclein is abundant in structures known as Lewy bodies – a diagnostic hallmark of Parkinsons disease.
Elizabeth Crown | EurekAlert!
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