Uppsala University scientists have developed a new method for measuring the concentration of the messenger substance for cells, cyclic adenosine monophosphate (cAMP), in individual living cells. Thanks to this method, the researchers have been able to see how the same messenger molecule can regulate disparate cell functions. The findings will probably be of great value in the development of new drugs for diabetes, among other diseases. The study is being published in the scientific journal Nature on January 19.
Cyclic adenosine monophosphate (cAMP) is a messenger molecule that transmits signals from the cell surface to govern a number of different functions inside the cell. cAMP is vital for the regulation of metabolism, ion channel activity, secretion, and genetic expression, for instance. In insulin-producing cells cAMP serves as a powerful booster of insulin release.
Four Uppsala researchers have developed a new method that makes it possible to measure the concentration of cAMP in individual living cells. With the new method the scientists have studied insulin-producing cells and found that stimulation with hormones leads to regular variations in the concentration of cAMP.
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