Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

OHSU researchers discover protein fragment that helps predict breast cancer outcome

17.01.2006


Oregon Health & Science University Cancer Institute researchers have identified a protein fragment in some human breast cancers that may help predict a patient’s chances of survival.



The presence of the fragment, called p95HER-2, in breast cancer tissue correlates closely with lymph node metastasis and earlier recurrence of the disease, suggesting that p95HER-2 is a marker and perhaps even involved in metastasis.

"By studying this marker we have a better chance to identify the patients who are more likely to have a longer disease-free survival," said Edward Keenan, Ph.D., one of the authors of the study. Keenan is professor of physiology and pharmacology and associate dean for medical education, OHSU School of Medicine.


The study, conducted in the lab of Gail Clinton, Ph.D., professor of biochemistry and molecular biology, OHSU School of Medicine, in collaboration with Keenan and investigators in Spain led by Jose Baselga, M.D., will be published on Jan. 15 in Clinical Cancer Research, a journal published by the American Association for Cancer Research.

The study builds on observations the investigators have published over the last five years about the role of the HER-2 oncogene in breast cancer. HER-2, a growth factor receptor, is overexpressed in 20 to 30 percent of breast cancer cases, but it has had limited usefulness in predicting clinical outcomes, particularly in early-stage breast cancer.

Clinton’s lab identified a fragment of full-length p185HER-2 that results from HER-2 cleavage, called p95HER-2, and developed an antibody that recognized it, making it possible to study the role of p95HER-2 in the spread of breast cancer.

The researchers studied breast cancer tissue from 483 biopsies from hospitals in the United States and Spain representing all stages of the disease. Two forms of the HER-2 protein were investigated: the full-length p185HER-2 receptor and its truncated form, p95HER-2. Only the truncated form proved to be a significant independent prognostic factor regarding clinical outcomes.

"More work is needed to determine if the presence of p95 has any significance regarding responsiveness of the cancers to chemotherapy, anti-estrogen therapy or Herceptin [a drug therapy for HER-2-related metastatic breast cancer]," Keenan said. "Hopefully, understanding the significance of this marker will help us better specify effective therapy for individual patients."

Rachel MacKnight | EurekAlert!
Further information:
http://www.ohsu.edu

More articles from Life Sciences:

nachricht Researchers identify how bacterium survives in oxygen-poor environments
22.11.2017 | Columbia University

nachricht Researchers discover specific tumor environment that triggers cells to metastasize
22.11.2017 | University of California - San Diego

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Nanoparticles help with malaria diagnosis – new rapid test in development

The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.

Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

Researchers at IST Austria define function of an enigmatic synaptic protein

22.11.2017 | Life Sciences

Fine felted nanotubes: CAU research team develops new composite material made of carbon nanotubes

22.11.2017 | Materials Sciences

Women and lung cancer – the role of sex hormones

22.11.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>