Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

MBL leads effort to update E. coli genome

10.01.2006


Project aims to consolidate information, coordinate efforts



E.coli is one of the most important model organisms for molecular science today and is arguably the single organism about which the most is known. The genes of higher-level plants and animals, even humans, are often understood by their similarity to E. coli genes. As such, the accuracy and completeness of E.coli genome information is of great importance to the scientific community.

In an attempt to consolidate the efforts of scientists working independently on the genome of the E.coli K-12 strain, an international team of biologists, led by MBL (Marine Biological Laboratory) scientists Monica Riley and Margrethe "Gretta" Serres, has published a comprehensive, updated description of all 4,500 E. coli K-12 genes. The data is presented in the January 5, 2006 online issue of the journal Nucleic Acids Research.


"The E. coli scientific community is scattered," said Riley, a senior scientist in the MBL’s Josephine Bay Paul Center for Comparative Molecular Biology and Evolution. "We determined that we needed to get together and pool everything we know into one package. E. coli is one of the most important model organisms for molecular science today. Our work will help move this forward."

A group of 19 scientists from four countries updated the annotation of E. coli K-12 at two MBL workshops organized by Riley and Serres. Annotation involves identification of genes, and their starting and ending sites, as well as the description of gene products. The process helps scientists to determine gene function.

During the MBL workshops, Riley and her colleagues assigned known or predicted gene functions to each E. coli K-12 product based on previously known experimental evidence or sequence analysis. "We cooperated to an amazing extent, reviewing every single one of 4,500 genes of E. coli K-12," said Riley. The scientists developed the best consensus on the status and properties of each of the E.coli K-12 genes at the present moment. Their goal was not to create a new database, but to present a comprehensive, updated annotation of E.coli K-12, which would be readily available to the public. "Our work puts a searchlight on the fraction of E. coli genes that are unknown and will accelerate laboratory work on the unknown functions with the goal of knowing what every gene does in the living organism," said Riley.

According to Riley, currently there is no funding by an agency for any kind of coordinated E. coli annotation effort, however interested members of the E. coli community are applying to NIH for support to establish a K-12 information resource. "Interaction among the scientists accelerates discovery and the hope is that this kind of work will soon be centralized," she said. "This would provide more efficient coordination of scientific groups that are working independently."

Gina Hebert | EurekAlert!
Further information:
http://www.mbl.edu
http://nar.oxfordjournals.org/current.dtl#1

More articles from Life Sciences:

nachricht Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery
20.01.2017 | GSI Helmholtzzentrum für Schwerionenforschung GmbH

nachricht Seeking structure with metagenome sequences
20.01.2017 | DOE/Joint Genome Institute

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>