Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Scientists Develop Prototype Drug to Prevent Osteoporosis Based on Cannabinoids Produced by Body

03.01.2006



Substances produced in the body that act like those found in the cannabis plant help preserve bone density, according to researchers at the Hebrew University of Jerusalem. Based on this finding, a prototype for a new drug to prevent osteoporosis (loss of bone density) without any psychoactive side effects has already been developed.

An article describing this research appears this week in the prestigious American journal PNAS (Proceedings of the National Academy of Sciences of the U.S.A.). The researchers, from the Bone Laboratory of the Hebrew University, are headed by Prof. Itai Bab, working in cooperation with Prof. Esther Shohami of the Laboratory for the Study of Bain Trauma; Prof. Raphael Mechoulam of the Hebrew University School of Pharmacy; doctoral students Orr Ofek, Vardits Krem and Yossi Tam; and master’s degree student Meirav Fogel.

Substances made in the body called endocannabinoids are composed mainly of fatty acids which were discovered during the last 15 years. (The fatty acid anandamid was discovered by Prof. Mechoulam in 1992.) These materials, which are produced mainly in the brain, are present also in the bone and other tissues and have similar effects to those of the active components in hashish and marijuana, produced from the cannabis plant.



These substances bind to and activate two receptors, CB1 and CB2. The first is found in the nervous system and is responsible for the psychoactive effects of the active components in the cannabis plant and endocannanoids. The second receptor is found in the immune system. It is not known to be involved with psychoactive responses, and there has been little information about its physiological function.

The Hebrew University researchers discovered a high level of CB2 receptors in bone, and that this is required in order to preserve normal bone density. Together with their colleagues at the University of Bonn, Germany, Prof. Andreas Zimmer and Dr. Malia Karasek, they studied the skeletons of genetically engineered mice lacking the CB2 receptor. As they aged, these CB2-deprived mice developed severe osteoporosis, similar to that which appears in humans. Osteoporosis is the most widespread degenerative disease in developed countries and can lead to multiple fractures, disability and complications, and even death.

The scientists’ findings have thus assigned, for the first time, a physiological function to CB2 in preserving bone density and showed that it stimulates bone building and reduces bone loss. This indicates that substances that active the CB2 receptor can be used as basis for the development of drugs for osteoporosis patients. Indeed, the Hebrew University researchers have developed a new synthetic compound, HU-308, which activates CB2 and slows the development of osteoporosis in mice. This compound forms the basis for a cannabinoid-based, anti-osteoporotic type drug which has also been found to be free of any psychoactive side effects.

The Hebrew University research was conducted within the framework of a project directed at clarifying the connection between the brain, behavior and changes in skeletal structure. The research was funded by the Bikura (First) Program of the Israel Science Foundation, which supports pioneering, innovative, interdisciplinary projects. The research also received funding from the U.S. National Institutes of Health.

Jerry Barach | alfa
Further information:
http://www.huji.ac.il

More articles from Life Sciences:

nachricht Scientists spin artificial silk from whey protein
24.01.2017 | Deutsches Elektronen-Synchrotron DESY

nachricht Choreographing the microRNA-target dance
24.01.2017 | UT Southwestern Medical Center

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Scientists spin artificial silk from whey protein

X-ray study throws light on key process for production

A Swedish-German team of researchers has cleared up a key process for the artificial production of silk. With the help of the intense X-rays from DESY's...

Im Focus: Quantum optical sensor for the first time tested in space – with a laser system from Berlin

For the first time ever, a cloud of ultra-cold atoms has been successfully created in space on board of a sounding rocket. The MAIUS mission demonstrates that quantum optical sensors can be operated even in harsh environments like space – a prerequi-site for finding answers to the most challenging questions of fundamental physics and an important innovation driver for everyday applications.

According to Albert Einstein's Equivalence Principle, all bodies are accelerated at the same rate by the Earth's gravity, regardless of their properties. This...

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Breaking the optical bandwidth record of stable pulsed lasers

24.01.2017 | Physics and Astronomy

Choreographing the microRNA-target dance

24.01.2017 | Life Sciences

Spanish scientists create a 3-D bioprinter to print human skin

24.01.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>