Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Gene Linked With Precursor to Visual Loss

29.11.2005


Gene is associated with increased risk of precursor of macular degeneration



A variant in a gene called Complement Factor H (CFH) appears to contribute to the increased risk of advanced age-related macular degeneration (AMD) largely or entirely through its impact on the development of a precursor of advanced AMD called soft drusen (small yellowish, extracellular deposits of lipid, protein and cellular debris in the back of the eye), according to a multinational team of researchers.

Several research groups recently showed that CFH increases the risk for advanced AMD. However until this study, the relationship between CFH, soft drusen, and advanced AMD was unclear.


In an article to be published online on November 29 by PLoS Medicine, the researchers working at the deCODE genetics Inc., Reykjavik, Iceland, the Moran Eye Center and Eccels Institute of Human Genetics of the University of Utah, USA, and the University of Iceland, found that CFH is a major risk factor for soft drusen. The researchers looked at the CFH gene and its relationship with the presence of soft drusen and AMD in 581 Icelandic patients with advanced and 435 with early AMD, and also 322 US patients with advanced and 109 with early AMD.

AMD is the most common cause of visual loss and is preceded by formation of soft drusen. However, only a portion of patients who develop soft drusen will go on to develop advanced AMD. “We have discovered that the CFH variant is a major risk factor for soft drusen, but does not appear to determine who ultimately progresses to advanced AMD, as previously proposed” , said Dr. Kristinn P. Magnusson, who led the deCODE genetics research team with Dr. Jeffrey Gulcher. Dr. Kang Zhang led the University of Utah team. The authors conclude that it is likely that there are other important genes yet to be found that contribute to the risk of age-related macular degeneration, especially among those who already have soft drusen.

Citation: Magnusson KP, Duan S, Sigurdsson H, Petursson H, Yang Z, et al. (2006) CFH Y402H confers similar risk of soft drusen and both forms of advanced AMD. PLoS Med 3(1): e5.

Paul Ocampo | alfa
Further information:
http://www.plos.org
http://dx.doi.org/10.1371/journal.pmed.0030005
http://www.plosmedicine.org

More articles from Life Sciences:

nachricht Cells communicate in a dynamic code
19.02.2018 | California Institute of Technology

nachricht Studying mitosis' structure to understand the inside of cancer cells
19.02.2018 | Biophysical Society

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: In best circles: First integrated circuit from self-assembled polymer

For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.

In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

Im Focus: Hybrid optics bring color imaging using ultrathin metalenses into focus

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Im Focus: Stem cell divisions in the adult brain seen for the first time

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...

Im Focus: Interference as a new method for cooling quantum devices

Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters

Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Contacting the molecular world through graphene nanoribbons

19.02.2018 | Materials Sciences

When Proteins Shake Hands

19.02.2018 | Materials Sciences

Cells communicate in a dynamic code

19.02.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>