Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Scientists move forward understanding of schizophrenia

18.11.2005


A Scots-led medical research team has identified a new gene linked to major mental illness that links back to a previously discovered gene known to increase the risk of schizophrenia and depression. Scientists from the Universities of Edinburgh and Glasgow, together with scientists from the pharmaceutical company Merck, Sharp & Dohme Limited, report the discovery of the second gene, phosphodiesterase 4B (PDE4B) in the prestigious journal Science today (17 November). Their discoveries could lead to the eventual development of new drugs to treat mental health problems.



In 2000, researchers at the University of Edinburgh identified a gene they called Disrupted in Schizophrenia 1 (DISC1), which was found to increase the chances of people developing schizophrenia, bipolar disorder (manic depression) and major clinical depression.

Now, new research by the two Universities and by scientists from the pharmaceutical company Merck Sharpe and Dohme reveals that damage to the gene PDE4B is also seen to increase the risk of developing mental illness. PDE4B was already known to play an important role in how the brain thinks and builds memories, but had not previously been linked to mental disorder. In addition, researchers have discovered that DISC1 acts as a regulator for PDE4B, creating a ’pathway’ between the two genes.


Professor David Porteous at the University of Edinburgh said: "This is another important breakthrough in our still limited understanding of major mental illness. It is the result of a long term research commitment to use the tools of genetics to better understand the root causes of mental disorder.

"This has been a fantastic combined effort. The collaboration between the Universities of Edinburgh and of Glasgow, jointly with our research colleagues at Merck Sharpe and Dohme has really made this happen.

"It is now clear that the DISC1 gene plays an important role in the risk of developing schizophrenia or bipolar affective disorder. The new genetic link we have made to PDE4B and how that links back to DISC1 sheds much needed light on these debilitating disorders. It also suggests a new way of thinking about developing better and effective medicines."

Professor Miles Houslay of the University of Glasgow said: "Over the past few years we’ve been working hard to help in the development of medicines for treating asthma and chronic obstructive pulmonary disease by inhibiting very similar enzymes to PDE4B. It has been so exciting to work together with the Edinburgh and Merck groups in finding this new link between the gene coding for PDE4B and schizophrenia. This new research has the potential for developing novel ways of diagnosing and treating this debilitating disease."

Peter Hutson, the Neuroscience Research Centre, Merck Sharp & Dohme, said: "Mental illness remains a scourge of society. Our insights into the important role that the proteins PDE4B and DISC1 may play in the mis-function of the brain that leads to schizophrenia will lead our thinking in the development of new treatments for this disorder"

David Porteous | EurekAlert!
Further information:
http://www.ed.ac.uk

More articles from Life Sciences:

nachricht How brains surrender to sleep
23.06.2017 | IMP - Forschungsinstitut für Molekulare Pathologie GmbH

nachricht A new technique isolates neuronal activity during memory consolidation
22.06.2017 | Spanish National Research Council (CSIC)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Individualized fiber components for the world market

23.06.2017 | Physics and Astronomy

How brains surrender to sleep

23.06.2017 | Life Sciences

Can we see monkeys from space? Emerging technologies to map biodiversity

23.06.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>