Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Expression Project for Oncology (expO) collects 1,000th malignant tumor specimen


Clinically annotated results are publicly available online

The International Genomics Consortium’s (IGC) Expression Project for Oncology (expO) today announced that it has collected its 1,000th frozen cancer specimen, which exceeds original expectations for the project while marking a milestone that is recognized by researchers, industry and academia. Gene expression analysis with clinical information on hundreds of these specimens is now publicly available online.

The purpose of expO is to obtain cancer tissue samples under uniform and standardized conditions, perform gene expression analyses, and collect the long-term clinical outcome of the patient. The data is both collected and shared in a way to ensure the protection of patient confidentiality, while still making the "de-identified" information available online for researchers worldwide. Open and free access to the data will accelerate genetic discoveries and the development of tests and therapies.

"We overcame many challenges to perform complete gene analyses and to have the information freely available online, while also ensuring that we had addressed key issues of patient privacy and consent is a major step forward," said Robert Penny, M.D., Ph.D., Executive Director of expO and Chief Medical Officer of IGC. "Going from zero to 1,000 tumor samples in 16 months was also a considerable feat."

IGC has established a standardization system for obtaining and processing these tumor samples. This standardization of the collection, analysis, and vocabularies will help accelerate future development of new, targeted cancer treatments.

Tissue collection and data dissemination is conducted in a manner that fully protects patient privacy. Over a three-year period, IGC expects to obtain 2,000 to 3,000 tumor specimens representing a broad spectrum of malignancies and 500-1,000 normal tissues. The project is well on its way to meeting this goal. So far, IGC has collected a total of 5,083 biospecimens including frozen biosamples and paraffin tissue blocks containing normal, paranormal and malignant tissue and peripheral blood samples.

"What IGC has accomplished in terms of the expO project could potentially accelerate cancer research," said Franklyn G. Prendergast, M.D., Ph.D., Director of the Mayo Clinic Cancer Center and the Edmond and Marion Guggenheim Professor of Biochemistry and Molecular Biology at the Mayo Medical School. "This publicly available database provides researchers with access to a vast amount of useful cancer information that will ultimately help the community advance its search for new treatments for this devastating disease."

The success of this national philanthropic initiative is due in part to the leadership, vision, and financial support of GlaxoSmithKline, Bristol-Myers Squibb and Wyeth pharmaceuticals.

"The expO database illustrates how industry can partner with academia, hospitals, and non-profit medical research organizations to create a freely available resource that will promote and accelerate discovery.," said Nicholas C. Dracopoli, Ph.D., Vice President of Clinical Discovery Technologies at Bristol-Myers Squibb.

The clinically annotated dataset is available in the public domain through the National Center for Biotechnology Information web site at

Galen Perry | EurekAlert!
Further information:

More articles from Life Sciences:

nachricht International team discovers novel Alzheimer's disease risk gene among Icelanders
24.10.2016 | Baylor College of Medicine

nachricht New bacteria groups, and stunning diversity, discovered underground
24.10.2016 | DOE/Lawrence Berkeley National Laboratory

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

New method increases energy density in lithium batteries

24.10.2016 | Power and Electrical Engineering

International team discovers novel Alzheimer's disease risk gene among Icelanders

24.10.2016 | Life Sciences

New bacteria groups, and stunning diversity, discovered underground

24.10.2016 | Life Sciences

More VideoLinks >>>