A team of researchers at Virginia Commonwealth University Massey Cancer Center has discovered an entirely new mechanism of action for a novel pharmacological agent currently in clinical trials in patients – the kinase inhibitor BAY 43-9006 – which was designed to disrupt the survival pathways of tumor cells.
“This agent was originally designed to inhibit the Raf-1 pathway, which is frequently mutated in many types of cancers, including leukemia,” said Steven Grant, M.D., Massey’s principal investigator for the study that was published in the Oct. 21 issue of the Journal of Biological Chemistry. BAY 43-9006 is a new agent known to induce apoptosis, or cell death, in a variety of tumor cells, presumably by interrupting this pathway. The agent was made available to Massey’s researchers by the National Cancer Institute.
“We were surprised to find that the killing effects of Bay 43-9006 in human leukemia cells had very little to do with inhibition of the Raf-1 pathway,” Grant said. “Instead, the major mechanism of lethality of this compound involved down-regulation of a protein known as Mcl-1, which plays a critical role in protecting leukemic cells from apoptosis.
Transport of molecular motors into cilia
28.03.2017 | Aarhus University
Asian dust providing key nutrients for California's giant sequoias
28.03.2017 | University of California - Riverside
The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
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