Silencing Alzheimers: targeting a key enzyme with gene therapy reversed course of disease in mouse models
In mice, that had been genetically engineered to develop Alzheimers disease, scientists were able to reverse the rodents memory loss by reducing the amount of an enzyme that is crucial for the development of Alzheimers disease.
"What we are showing is a proof of principle that stopping the synthesis of a protein that is necessary for the formation of the telltale plaques reverses the progression of the disease, and more importantly, the cognitive function of these mice, which had already been impaired, has now recovered," says Inder Verma, professor in the Laboratory for Genetics at the Salk Institute for Biological Studies.
Cathy Yarbrough | EurekAlert!
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