The tissue-specific elongation factor eEF1A2 might be an oncoprotein involved in breast cancer. Research published in the open access journal BMC Cancer shows that eEF1A2, which is usually present only in muscle cells and neurons, is abnormally expressed in two thirds of breast tumours. This means it could be used as a new diagnostic marker and, once its role as been identified, as a therapeutic target for the treatment of breast tumours.
Catherine Abbott, Victoria Tomlinson and colleagues, from the University of Edinburgh in the UK, studied the expression of eEF1A2 in breast tumour cells both at the RNA and at the protein level. The results from both analyses show that eEF1A2 is moderately to highly expressed in two-thirds of malignant tumour cells, whereas the protein is only barely expressed in normal breast cells; the expression of eEF1A2 is up to 30-fold higher in tumour cells than in normal cells. Over-expression is considerably more significant in tumour cells bearing the estrogen receptor (ER) than in ER-negative tumour cells: 18% of ER-negative tumours showed slight expression of eEF1A2, whereas 63% of ER-positive tumours showed significant expression of the protein.
Recent studies had shown that eEF1A2 is over-expressed in ovarian cancer cells, but the protein had not been shown to be expressed in breast cancer cells. More research is needed to identify its exact role in the development of breast tumours. "The oncogenicity of eEF1A2 may be related to its role in protein synthesis or to its potential non-canonical functions in cytoskeletal remodelling or apoptosis", write the authors.
Juliette Savin | EurekAlert!
Water forms 'spine of hydration' around DNA, group finds
26.05.2017 | Cornell University
How herpesviruses win the footrace against the immune system
26.05.2017 | Helmholtz-Zentrum für Infektionsforschung
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
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Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
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An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
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26.05.2017 | Life Sciences
26.05.2017 | Life Sciences
26.05.2017 | Physics and Astronomy