The tissue-specific elongation factor eEF1A2 might be an oncoprotein involved in breast cancer. Research published in the open access journal BMC Cancer shows that eEF1A2, which is usually present only in muscle cells and neurons, is abnormally expressed in two thirds of breast tumours. This means it could be used as a new diagnostic marker and, once its role as been identified, as a therapeutic target for the treatment of breast tumours.
Catherine Abbott, Victoria Tomlinson and colleagues, from the University of Edinburgh in the UK, studied the expression of eEF1A2 in breast tumour cells both at the RNA and at the protein level. The results from both analyses show that eEF1A2 is moderately to highly expressed in two-thirds of malignant tumour cells, whereas the protein is only barely expressed in normal breast cells; the expression of eEF1A2 is up to 30-fold higher in tumour cells than in normal cells. Over-expression is considerably more significant in tumour cells bearing the estrogen receptor (ER) than in ER-negative tumour cells: 18% of ER-negative tumours showed slight expression of eEF1A2, whereas 63% of ER-positive tumours showed significant expression of the protein.
Recent studies had shown that eEF1A2 is over-expressed in ovarian cancer cells, but the protein had not been shown to be expressed in breast cancer cells. More research is needed to identify its exact role in the development of breast tumours. "The oncogenicity of eEF1A2 may be related to its role in protein synthesis or to its potential non-canonical functions in cytoskeletal remodelling or apoptosis", write the authors.
Juliette Savin | EurekAlert!
Cancer diagnosis: no more needles?
25.05.2018 | Christian-Albrechts-Universität zu Kiel
Less is more? Gene switch for healthy aging found
25.05.2018 | Leibniz-Institut für Alternsforschung - Fritz-Lipmann-Institut e.V. (FLI)
The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.
Vehicles already offer diverse communication interfaces and more and more automated functions, such as distance and lane-keeping assist systems. At the same...
A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.
The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...
At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...
There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
25.05.2018 | Event News
02.05.2018 | Event News
13.04.2018 | Event News
25.05.2018 | Event News
25.05.2018 | Machine Engineering
25.05.2018 | Life Sciences