If living cell is replaced by a test-tube with DNA and a set of substances, it is possible to get proteins in a more simple and inexpensive way. That was done by Russian biochemists synthesizeing insulin without help of transgene Escherichia coli. The researchers’ concept was funded by the Ministry of Science and Molecular and Cellular Boioplogy, Russian Academy of Sciences.
Insulin for diabetics has been obtained so far by utilizing biotechnological synthesis. The basic material for the presious hormone – proinsulin protein – is obtained from transgene Escherichia coli, which is grown up in large quantities. However, Russian researchers have decided that it is too complicated to educe a single protein from an entire, although tiny organism, and invented a way to do without bacteria. Specialists of the Institute of Protein (Russian Academy of Sciences), Moscow State University and Institute of Bio-organic Chemistry decided to replace live bacteria by their extract and artificial reactor.
Biochemists involved a reactor of German production for proinsulin synthesis. The reacting mixture was placed in it, the mixture consisting of Escherichia coli extract, its transfer RNA, enzymes (that are in charge of manipulation with nucleic acids), amino acids and mineral salts. The matrix, from which proinsulin molecules were “printed”, was an artificially acquired plasmid – DNA molecule coding the sequence of amino acids in proinsulin.
Sergey Komarov | alfa
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